强直性脊柱炎免疫遗传学发病机制的研究进展

Research progress of immunogenetic pathogenesis of ankylosing spondylitis

强直性脊柱炎(AS)是常见的、免疫介导的炎症性关节炎,主要累及中轴关节,好发于青年男性。AS的发病可能是遗传、免疫和环境因素共同作用的结果。近5年来,AS免疫遗传学发病机制的研究取得了较大进展。本文对有关主要组织相容性复合体(MHC)基因、非MHC基因、肠道黏膜免疫以及内质网氨基肽酶(ERAP)参与AS发病的最新研究发现进行综述。

Ankylosing spondylitis (AS) is a common immune-mediated inflammatory arthritis of the axial skeleton that predominantly affects young men. The onset of AS is likely to be a result of the combined action of genetic, immunological, and environmental factors. Over the past five years, great progress has been made in the study of immunogenetic pathogenesis of AS. In this article, the roles of the major histocompatibility complex (MHC) gene, the non-MHC gene, gut mucosal immunity, and endoplasmic reticulum aminopeptidase (ERAP) in the AS pathogenesis were reviewed.