盐酸吗啡注射液输液稳定性研究

Study on the Stability of Morphine Hydrochloride Injection During Infusion

目的探讨盐酸吗啡注射液在不同输液条件下的稳定性。方法模拟临床常用给药剂量,将盐酸吗啡注射液分别储存于自控镇痛泵、玻璃瓶、普通注射器中,分别于25℃和37℃放置0,1,2,3,5,7,9,11,13,15 d,采用高效液相色谱法测定盐酸吗啡的质量浓度,以pH复合电极测定p H。结果在25℃或37℃条件下,盐酸吗啡注射液在3种容器中放置15 d内,其外观及pH均无明显变化,盐酸吗啡注射液质量浓度基本平稳。结论无论是室温还是体温条件下,盐酸吗啡注射液置玻璃瓶、普通注射器、自控镇痛泵中15 d内均稳定。

Objective To investigate the stability of Morphine Hydrochloride Injection under different infusion conditions.Metliods By simulating the dosage commonly used in the clinic,Morphine Hydrochloride Injection was stored in the patient-controlled analgesia pump,glass bottle and common syringe at 25℃or 37℃for 0,1,2,3,5,7,9,11,13,15 d,respectively.The mass concentration of morphine hydrochloride was determined by HPLC,and the pH was determined by pH composite electrode.Results The appearance and pH of Morphine Hydrochloride Injection had no obvious change in the three containers within 15 d at 25℃or 37℃,and the mass concentration of Morphine Hydrochloride Injection remained stable.Conclusion Whether at room temperature or body temperature,Morphine Hydrochloride Injection was stable in the glass bottle,common syringe and patient-controlled analgesia pump within 15 d.