肠道微生态与酒精性肝病

Intestinal microflora and alcoholic liver disease

肠道正常菌群及其所构成的微生态是人体正常生理功能所必需。酒精性肝病时存在肠道微生态失衡,表现为菌群数量、构成比的紊乱,肠黏膜屏障功能破坏、细菌易位及肠源性内毒素血症等,在酒精性肝病的发生发展中具有重要作用。同时肠道菌群对酒精的代谢也有重要影响。益生菌制剂或粪菌移植调整肠道微生态有望对酒精性肝病产生积极的治疗作用。在酒精性肝病的防治中,如何规范使用微生态制剂、选择合适的剂量、剂型及疗程等均值得进一步探讨。

Normal intestinal microflora and microecology are essential for normal physiological functions in human body. Intestinal microflora imbalance is often observed in patients with alcoholic liver disease and manifests as abnormal number and constituent ratio of intestinal microflora, dysfunction of intestinal mucosal barrier, bacterial translocation, and intestinal endotoxemia, and it plays an important role in the development and progression of alcoholic liver disease. In addition, intestinal microflora also has influence on alcohol metabolism. Probiotics or fecal microbiota transplantation can regulate intestinal microflora and may play an active role in the treatment of alcoholic liver disease. Further studies are needed to discuss the standardized use of microecologics, dose selection, dosage form, and course of treatment during the prevention and treatment of alcoholic liver disease.