摘要
随着核苷(酸)类似物(NAs)在慢性乙型肝炎抗病毒治疗中的广泛应用,NAs长期应用的副作用引起临床医生和患者越来越多的关注。近年来,NAs治疗慢性乙型肝炎患者相关肌损伤的报道逐年增多,对其发生率、发病机制及处理的认识也逐步深入。对NAs相关肌损伤发生率及相关因素、临床表现、发病机制、管理及防治等方面进行了综述。
With the wide application of nucleos(t)ide analogues (NAs) in antiviral therapy for chronic hepatitis B (CHB), the side effects of NAs after long-term use have attracted more and more attention from clinicians and patients. In recent years, an increasing number of studies have reported muscle injury in CHB patients treated with NAs, and we have gained a deeper understanding of the incidence rate, pathogenesis, and treatment of muscle injury. This article reviews the incidence rate, related factors, clinical manifestations, pathogenesis, management, and prevention and treatment of muscle injury associated with NAs.
作者
袁灵
曾白梅
林世德
YUAN Ling;ZENG Baimei;LIN Shide(Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou 563003, China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第3期627-630,共4页
Journal of Clinical Hepatology
基金
国家自然科学基金资助项目(81460124/H0316)。
关键词
肝炎
乙型
慢性
核苷类
核苷酸类
肌损伤
综述
hepatitis B, chronic
nucleosides
nucleotides
muscle injury
review