HDV感染的流行病学、发病机制及诊疗进展

Research advances in epidemiology, pathogenesis, and diagnosis and treatment of hepatitis D virus infection

HBV/HDV合并感染可导致肝病进展加速,但由于HDVRNA等检测方法学尚存在一定局限,HDV的流行病学尚不十分清楚;HDV导致HBV/HDV共感染者的发病机制及其治疗措施也需要进一步探讨。通过回顾我国以及其他国家HDV流行病学特征、HDV特异性免疫与基因型发病机制,并总结HDV的检测方法及治疗方法,分析表明现有HDV感染的检测方法敏感度、特异度低,也无标准化检测方法;探究新的HDV感染检测方法,将有助于研发新型有效抗的HDV药物,对提高HDV感染的疗效具有重要意义。

Hepatitis B virus (HBV)/hepatitis D virus (HDV) co-infection can accelerate the progression of liver diseases, but due to the limitations of the detection methods for HDV RNA, the epidemiology of HDV remains unclear. Further studies are needed to investigate the pathogenesis of HBV/HDV co-infection caused by HDV and related treatment methods. By reviewing the epidemiological features of HDV, HDV-specific immunity, genotype, and pathogenesis in China and other countries and summarizing HDV detection methods and treatment methods, this article shows that current detection methods for HDV infection have low sensitivity and specificity, with a lack of standardized detection methods. Exploration of new HDV detection methods will help to develop new and effective anti-HDV drugs, which has great significance in improving the outcome of HDV infection.