替格瑞洛和氯吡格雷对急性心肌梗死行经皮冠状动脉介入治疗患者的疗效对比

Comparison of Efficacy of Tiglilo and Clopidogrel in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention

目的对比给予急性心肌梗死(AMI)溶栓及择期行经皮冠状动脉介入治疗(PCI)患者应用替格瑞洛及氯吡格雷的效果。方法将74例AMI患者随机分成观察组(37例)与对照组(37例),两组均行溶栓及择期PCI治疗,在治疗基础上,给予观察组患者加用替格瑞洛治疗,给予对照组患者氯吡格雷治疗,观察两组患者的治疗效果。结果观察组治疗后血小板计数高于治疗前及对照组治疗后,血小板最大聚集率及肌酐均低于治疗前及对照组治疗后,差异均具有统计学意义(P <0.05)。结论同氯吡格雷相比,应用替格瑞洛可有效抑制AMI患者PCI治疗后血小板聚集。

Objective To compare the effects of tiglilo and clopidogrel on patients with acute myocardial infarction(AMI)and selective percutaneous coronary intervention(PCI).Methods 74 patients with AMI were randomly divided into observation group(37 cases)and control group(37 cases).Thrombolysis and selective PCI were performed in both groups.On the basis of treatment,the patients in the observation group were treated with tegrilol.The patients in the control group were treated with clopidogrel.The therapeutic effect of the two groups was observed.Results After treatment,the platelet count in the observation group was higher than that before treatment and after treatment in the control group.The maximum platelet aggregation rate and creatinine in the observation group were lower than that before treatment and after treatment in the control group.The difference was statistically significant(P<0.05).Conclusion Compared with clopidogrel,tigrel can effectively inhibit platelet aggregation in patients with AMI after PCI.