β-catenin及ABCG-2在子宫肉瘤组织中的表达及其意义

Expression of β-catenin and ABCG-2 in the Sarcoma of Uterus and the Clinical Significances

目的比较β-catenin及ABCG-2蛋白在子宫肉瘤组织、子宫平滑肌瘤组织及正常子宫平滑肌组织中的表达,探讨其在子宫肉瘤发病中的作用。方法采用免疫组化SP二步法检测β-catenin及ABCG-2蛋白在子宫肉瘤组织中的表达,比较二者在不同病理类型,不同恶性程度以及不同临床分期的子宫肉瘤中的表达差异,并对二者的表达水平进行相关性分析。结果子宫肉瘤组织中β-catenin、ABCG-2蛋白阳性表达率明显高于子宫平滑肌瘤及正常子宫平滑肌组织(P<0.05);子宫平滑肌瘤组织及正常子宫平滑肌组织中β-catenin、ABCG-2蛋白的阳性表达率比较,差异无统计学意义(P>0.05)。子宫平滑肌肉瘤组织中β-catenin、ABCG-2蛋白阳性表达率与子宫内膜间质肉瘤及子宫肉瘤组织比较,差异无统计学意义(P>0.05)。Ⅲ~Ⅳ期子宫肉瘤组织中β-catenin、ABCG-2蛋白阳性表达率明显高于Ⅰ~Ⅱ期子宫肉瘤组织(P<0.05)。结论β-catenin、ABCG2蛋白在子宫肉瘤组织中呈高表达,二者可能协同促进子宫肉瘤的发生发展。

Objective To compare the expressions of β-catenin protein and ABCG-2 protein in different types of uterine sarcoma, hysteromyoma and normal myometrium, and investigate the role of β-catenin protein and ABCG-2 protein in the pathogenesis of uterine sarcoma. Methods The expressions of β-catenin and ABCG-2 protein were detected in 90 cases of sarcoma of uterine by immunohistochemistry method, and were compared in different pathological types, malignant degrees and clinical stages of uterine sarcoma. The correlation of β-catenin expression with the ABCG-2 expression was also analyzed. Results The positive expression rates of β-catenin and ABCG-2 protein in the sarcoma of uterus were significantly higher than those in cellular uterine leiomyoma and normal uterine smooth muscle tissue (P<0.05). However, no significant differences were found between the leiomyoma of the uterus and normal uterine smooth muscle tissue (P>0.05). Yet there was no obvious difference in the β-catenin and ABCG-2 expression between leiomyoma of the uterus, endometrial stromal sarcoma and uterine carcinosarcoma (P>0.05). The positive expression rate of β-catenin and ABCG-2 protein in sarcoma of uterus at stage Ⅲ~Ⅳ were much higher than those at stage Ⅰ~Ⅱ(P<0.05). Conclusion The expressions of β-catenin and ABCG-2 protein were upregulated in the sarcoma of uterus. Both may synergistically promote the occurrence and development of uterine sarcoma.