替吉奥联合贝伐单抗对晚期直肠癌患者的效果及对癌胚抗原表达的影响

Effect of S-1 Combined with Bevacizumab on Patients with Advanced Rectal Cancer and the Levels of Carcinoembryonic Antigen

目的探讨替吉奥联合贝伐单抗对晚期直肠癌患者的效果及癌胚抗原表达检验。方法选取我院收治的晚期直肠癌患者62例,采用抽签法分为两组,对照组贝伐单抗注射液进行治疗,观察组在对照组基础上联合替吉奥治疗。检测两组患者的细胞因子水平、血清肿瘤标志物水平、免疫指标以及比较两组的不良反应。结果治疗前两组细胞因子水平无明显区别(P>0.05),治疗后观察组细胞因子水平低于对照组(P<0.05);治疗前两组患者的免疫指标无明显区别(P>0.05),治疗后观察组免疫指标高于对照组(P<0.05);观察组治疗后不良反应少于对照组(P<0.05);治疗前两组血清标志物无明显区别(P>0.05),治疗后观察组血清标志物水平低于对照组(P<0.05)。结论采取贝伐单抗联合替吉奥进行晚期直肠癌治疗,有着比较显著的治疗效果,可以将病人的免疫指标以及血清标志物水平进行有效改善,有着相对较高的安全性,值得临床中大力推广和使用。

Objective To explore the effect of S-1 combined with bevacizumab on the expression of carcinoembryonic antigen in patients with advanced rectal cancer. Methods Sixty-two cases of advanced rectal cancer treated in our hospital were selected and divided into two groups randomly. The control group was treated with bevacizumab injection, and the observation group was treated with S-1 combined with bevacizumab. Detect the cytokine levels, serum levels of tumor markers and immune indexes of the two groups, and compare the adverse reactions between the two groups. Results There was no significant difference in cytokine levels and immune indexes between the two groups before treatment (P>0.05). After treatment, the cytokine levels in the observation group were lower than in the control group (P<0.05), and the immune indexes in the observation group were higher than in the control group (P<0.05). The adverse reactions in the observation group were less than in the control group (P<0.05). No significant differences were found in serum markers between the two groups before treatment (P>0.05). But after treatment, the serum levels of tumor markers in the observation group were lower than in the control group (P<0.05). Conclusion The use of bevacizumab combined with S-1 for advanced rectal cancer has a significant therapeutic effect. It could effectively improve the immune index and serum marker levels of patients, and it has relatively high safety. So it could be widely used in clinical practice.