p16、Ki67在广州地区宫颈病变患者中的表达变化及临床意义

Relationship between the Expression of p16 and Ki67 in Cervical Lesions and Clinicopathological Features

目的探讨p16、Ki67蛋白在宫颈病变组织中的表达变化及其临床病理学特征意义。方法选取我院收集的40例宫颈癌组织、40例宫颈上皮内瘤变(CIN)组织、40例宫颈炎组织,采用免疫组织化学染色检测三组标本中的p16、Ki67蛋白表达情况,分析p16、Ki67蛋白与宫颈癌患者临床病理学特征的关系。结果宫颈癌组织中p16、Ki67蛋白阳性表达率均显著高于CIN组织和宫颈炎组织,差异均具有统计学意义(P<0.05);CIN组织中p16、Ki67蛋白阳性表达率均显著高于宫颈炎组织,差异均具有统计学意义(P<0.05);宫颈癌组织中p16、Ki67蛋白阳性表达主要与宫颈癌病理学分级、FIGO分期、发生淋巴结转移具有明显的相关性(P<0.05)。结论 p16、Ki67蛋白与宫颈癌的发生发展具有密切关系,可作为宫颈癌早期预警与诊断的参考指标。

Objective To investigate the expression changes of p16 and Ki67 in cervical lesions and their clinicopathological significance. Methods Collected from our hospital in this study were 40 cases of cervical cancer, 40 cases of cervical epithelioma (CIN) and 40 cases of cervicitis. Immunohistochemical staining was used to detect the expression of p16 and Ki67 protein of specimens in three groups. The relationship between p16 and Ki67 protein expression and clinicopathological characteristics of cervical cancer patients was analyzed. Results The positive rates of p16 and Ki67 expression in cervical cancer were significantly higher than those in CIN and cervicitis (P<0.05). And the positive rates of p16 and Ki67 in CIN were significantly higher than those in cervicitis (P<0.05). The positive expression of p16 and Ki67 protein in cervical cancer was mainly associated with pathological grade, FIGO stage and lymph node metastasis (P<0.05). Conclusion The expression of p16 and Ki67 proteins was closely related to the occurrence and development of cervical cancer. It could be taken as reference index for early diagnosis.