纳米佐剂在抗病毒疫苗中的应用

Applications of Nano-Adjuvant on the Vaccines Against Viral Infections

尽管投入了大量的人力物力,但仍有多种临床相关的病毒预防性疫苗未被开发出来,其中包括人免疫缺陷病毒等对人类健康产生严重威胁的病原体。目前,疫苗开发过程中的一些问题可以通过添加佐剂来解决。因为纳米颗粒的化学和结构特性具有提高免疫原性的功能,因此它们作为疫苗佐剂得到了广泛研究。纳米佐剂已应用到病毒疫苗领域中并获得了巨大的成功。本文旨在综述纳米佐剂的特点与分类及其在病毒疫苗中的应用。

Despite considerable manpower and material resources have been put,there are still many prophylactic vaccines for clinically relevant viruses have not been developed,including pathogens such as HIV that pose a serious threat to human health.Now,some problems in vaccine development can be solved by combined with adjuvants.Nanoparticles have been extensively studied as vaccine adjuvants because of their chemical and structural properties that improve immunogenicity.Nano-adjuvants have been achieved great success in the field of viral vaccines.The purpose of this review is to summarize the characteristics and classification of nano-adjuvants and their applications in viral vaccines.