卵母细胞成熟比例对卵胞浆内单精子注射助孕疗效的影响

The influence of oocyte maturation ratio on therapeutic effect of patients with ICSI cycle

目的探讨卵母细胞成熟比例对卵胞浆内单精子注射(ICSI)助孕患者疗效的影响。方法本研究纳入194例需行ICSI助孕治疗的患者,根据不同卵母细胞成熟的比例将患者分为A、B组,对两组患者ICSI受精率、卵裂率、可利用胚胎数、优质胚胎数、胚胎着床率、临床妊娠率及早期流产率等进行比较。结果两组患者大卵泡数、获卵率、促性腺激素(Gn)使用天数、Gn总剂量、人绒毛膜促性腺激素日子宫内膜厚度、可利用胚胎数、优质胚胎数、移植胚胎数、临床妊娠率、胚胎着床率及自然流产率比较,差异无统计学意义(P>0.05);两组患者小卵泡数、平均获卵数、ICSI受精率及卵裂率比较,差异有统计学意义(P <0.05)。结论卵母细胞成熟比例过低可能影响受精率及卵裂率,降低卵母细胞利用率。

Objective To investigate the effect of oocyte maturation ratio on the therapeutic effect of patients with ICSI cycle. Methods This study included 194 female infertility patients who required intracytoplasmic sperm injection (ICSI) for ART treatment. Patients were divided into two groups: oocyte maturation ratio ≥ 80% as group A (n = 107 cases), oocyte maturation ratio<80% as group B (n = 87 cases). ICSI fertilization rate, cleavage rate, available embryos, high quality embryos, implantation rate, clinical pregnancy rate and early abortion rate were compared between the two groups. Results There were no significant differences in the number of large follicles, the rate of oocyte acquisition, the days of gonadotropin (Gn) use, the total dose of Gn, the endometrial thickness on days of human chorionic gonadotropin, the number of available embryos, the number of high-quality embryos, the number of transferred embryos, the clinical pregnancy rate, the rate of embryo implantation and the rate of spontaneous abortion between the two groups (P > 0.05). There were significant differences in the number of small follicles, average number of eggs obtained, ICSI fertilization rate and cleavage rate between the two groups (P < 0.05). Conclusion Low oocyte maturation rate may affect fertilization rate and cleavage rate, and reduce oocyte utilization.