IL-33/ST2信号通路与骨代谢的研究进展

Research progress of IL-33/ST2 signaling pathway in bone metabolism

白细胞介素-33(interleukin-33,IL-33)是白细胞介素-1(interleukin-1,IL-1)细胞因子超家族的一个新成员,它可以激活肥大细胞、淋巴细胞、巨噬细胞,产生Th2细胞因子,并且在炎症、感染、自身免疫性疾病中发挥其重要作用。IL-33的经典信号途径是通过ST2和IL-1受体辅助蛋白(interleukin-1 receptor accessory protein,IL-1 RAcP)组成的异三聚体,将信号转导至细胞内。IL-33/ST2信号通路通过激活T、B淋巴细胞等方面影响骨代谢。本文就IL-33/ST2信号通路在骨代谢中的作用研究作一综述,复习文献结果表明,IL-33在骨代谢方面的作用仍存在争议,一些学者研究认为IL-33可抑制破骨细胞的生成,并且在生理性骨重建中起作用;但也有学者认为IL-33可促进破骨细胞的形成及分化,从而导致骨吸收。IL-33及其信号通路参与牙周炎及根尖周炎牙槽骨骨代谢,具体机制尚不清楚,还需进一步研究。

Interleukin-33(IL-33)is a new member of the interleukin-1(IL-1)cytokine superfamily.It can activate mast cells,lymphocytes and macrophages to produce Th2 cytokines and plays a very important role in inflammation,infection,and autoimmune disease.The classical signal pathway of IL-33 includes the isotrimer of ST2 and interleukin-1 receptor accessory protein(IL-1 RAcP),which transduces signals into cells.The IL-33/ST2 signaling pathway affects bone metabolism by activating T and B lymphocytes.This article reviews the role of the IL-33/ST2 signaling pathway in bone metabolism.The results of a literature review showed that at present,scholars at home and abroad still dispute the role of IL-33 in bone metabolism.Some scholars believe that IL-33 can inhibit osteoclast formation,and IL-33 has been recently implicated in physiological bone remodeling.However,other scholars believe that IL-33 can promote osteoclast formation and differentiation,which leads to bone absorption.IL-33 and its signaling pathway are involved in bone metabolism of alveolar bone in periodontitis and periapical periodontitis.The specific mechanism remains unclear,and further studies are warranted.