我院婴幼儿喘息常见病原体分布特点分析

Analysis of distribution characteristics of common pathogens in infants with wheezing

目的探讨引起婴幼儿喘息的常见病原体,为临床用药提供依据。方法收集我院儿科2016年1月1日—2017年1月1日收住院婴幼儿呼吸道感染患儿315例,采用免疫荧光法检测肺炎支原体(MP)、肺炎衣原体(CP)、嗜肺军团菌(LP)、甲型流感病毒(ifuA)、乙型流感病毒(ifuB)、副流感病毒(pful)、呼吸道合胞病毒(RSV)、腺病毒(Adv)Ig M抗体。结果常见呼吸道病原体检出率为27.9%,其中MP-Ig M检出率13.0%、CP-Ig M检出率4.1%、LP-Ig M检出率2.9%、R SV-Ig M检出率2.9%、ifuA-Ig M检出率1.6%、ifuB-Ig M检出率1.3%、pful-Ig M检出率1.3%、Adv-Ig M检出率0.95%。喘息组、非喘息组MP、CP、LP、R SV感染率比较差异有统计学意义(P<0.05)。MP、R SV在婴儿期及幼儿期两年龄段感染率差异有统计学意义(P<0.05)。结论患呼吸道感染的婴幼儿,特别是喘息患儿,行MP、CP、LP及R SV病原学检测对临床治疗有积极意义。

Objective To explore the common pathogens causing wheezing in infants,and to provide theoretical basis for clinical use. Methods A total of 315 hospitalized infants of our hospital with respiratory infection from January 1,2016 to January 1,2017 were enrolled.Immunofluorescence assay was used for Mycoplasma pneumoniae (MP) and Chlamydia pneumoniae (CP),Legionella pneumophila (LP),influenza virus (ifuA),influenza B virus (ifuB),parainfluenza virus (pful),respiratory syncytial virus (RSV),adenovirus (Adv) IgM antibody.Results The detection rate of common respiratory pathogens was 27.9%,including mp-igm detection rate of 13.0%,cp-igm detection rate of 4.1%,lp-igm detection rate of 2.9%,rsv-igm detection rate of 2.9%,ifua-igm detection rate of 1.6%,ifub-igm detection rate of 1.3%,pfu-igm detection rate of 1.3%,and Adv -igm detection rate of 0.95%.MP,CP,LP and RSV infection rates in the wheezing group and the non-wheezing group were significantly different(P<0.05).The infection rates of MP and RSV in infancy and early childhood were significantly different (P<0.05). Conclusion The detection of MP,CP,LP and RSV in patients with respirator infection,especially in patients with asthma,has positive significance for clinical treatment.