脑脊液降钙素原及乳酸测定在早期诊断颅脑术后颅内感染的意义

Diagnostic value of cerebrospinal fluid procaicitonin and lactic acid level in intracranial infection after craniotomy

目的研究降钙素原(PCT)及乳酸水平在早期诊断颅脑术后颅内感染的意义。方法颅脑术后颅内感染患者(n=20)和非颅内感染患者(n=20)的脑脊液和血液样本,检测脑脊液和血清PCT,脑脊液和血液乳酸水平等指标并进行统计分析。结果感染组脑脊液和血清PCT、乳酸水平较非感染组显著升高,差异有统计学意义(P<0.05)。脑脊液PCT和乳酸水平诊断敏感性及特异性均较血清PCT和乳酸水平高。结论脑脊液PCT、乳酸在颅脑手术术后颅内感染的诊断中均有意义,其中脑脊液PCT较乳酸敏感性更高,临床应用价值更大。

Objective To explore the diagnostic value of cerebrospinal fluid procalcitonin(PCT) and lactic acid level in intracranial infection after craniotomy. Methods Forty post-craniotomy patients with suspicious intracranial infection were chosen in our study;these patients were divided into infected group and disinfected group(n=20/each group). PCT and lactic acid level in the serum and cerebrospinal fluid were detected and analyzed,respectively. Results Both PCT and lactic acid values in the cerebrospinal fluid and PCT in serum in the infected group were significantly higher than those in the disinfected group(P<0.05). Both PCT and lactic acid in the CSF had good sensitivity and high specificity. Conclusion CSF PCT could be proposed as an effective diagnostic marker for intracranial infection and it is superior to CSF lactic acid,serum PCT and lactic acid count.