摘要
耐甲氧西林金黄色葡萄球菌(MRSA)广泛传播是全球重要的公共卫生问题。葡萄球菌染色体mec基因盒元件(SCCmec)在金黄色葡萄球菌中转移是导致MRSA广泛传播的重要原因。SCCmec中的mecA和mecC基因分别编码PBP2a和PBP2c,其结合β-内酰胺类抗菌药物能力低下,是导致MRSA发生的关键因素,而且mecA和mecC介导的耐药表型存在一定差异。本文就SCCmec的基本结构与功能、mecA与mecC介导的耐药机制与表型以及MRSA的检测方法等方面做以下综述。
The wide spread of methicillin-resistant Staphylococcus aureus(MRSA)is an important global public health problem.The transfer of Staphylococcal Cassette Chromosome mec(SCCmec)among Staphylococcus aureus is a key reason that MRSA spread widely.The mecA and mecC located in SCCmec encode PBP2a and PBP2c respectively.The low affinity for beta-lactams of PBP2a and PBP2c is a pivotal factor leading to the occurrence of MRSA.In addition,there are some differences between the mecA-mediated methicillin resistant phentype and the mecC-mediated.This paper reviews the basic structure and fuction of SCCmec,the mecA-and mecC-mediated methicillin resistant phentypes and mechanism and the detection methods of MRSA.
作者
李雪寒
李一荣
LI Xuehan;LI Yirong(Department of Clinical Laboratory,Zhongnan Hospital,Wuhan University,Wuhan,Hubei 430071,China)
出处
《国际检验医学杂志》
CAS
2019年第5期586-589,共4页
International Journal of Laboratory Medicine
基金
湖北省自然科学基金面上项目(2016CFB672)
