磁共振波谱技术的临床应用进展

Application of Magnetic Resonance Spectroscopy in Clinic(review)

磁共振波谱(MRS)能够直观定量分析组织的代谢情况。在康复领域中可用于脊髓损伤的预后判断、观察损伤后代谢变化;脑卒中后认知功能障碍评估、诊断及肌张力障碍机制研究;探索帕金森病的康复机制。在肿瘤中可用于前列腺癌和脑肿瘤的辅助诊断。除此之外,还应用于评估热射病的严重程度和预后,研究Duchenne肌营养不良症和多系统萎缩的发病机制。在动物实验中发现它可以优化实验设计方案。MRS也存在局限性,随着先进匀场算法等技术的发展将会被逐步突破。

Magnetic resonance spectroscopy (MRS) can directly and quantitatively analyze tissue metabolism. In the field of rehabilitation , it has been used in the prognosis of spinal cord injury, and observation of the metabolic changes after injury;in the diagnosis of stroke, cognitive dysfunction assessment, and dystonia mechanism research;exploring the rehabilitation mechanism of Parkinson's disease. It can be used in tumors for auxiliary diagnosis of prostate cancer and brain tumors. In addition, it can be used to assess the severity and prognosis of heat stroke, and to study the pathogenesis of Duchenne muscular dystrophy and multiple system atrophy. It was found in the animal experiments that it can optimize the experimental design. With the development of advanced shimming algorithms and other technologies, the limitations of MRS will be gradually broken.