托烷司琼复合氟哌利多、地塞米松预防全麻子宫切除术后恶心呕吐的作用分析

Analysis of the Effect of Tropisetron Combined with Droperidol and Dexamethasone on Prevention of Nausea and Vomiting after General Anesthesia Hysterectomy

目的探讨托烷司琼复合氟哌利多、地塞米松预防全麻子宫切除术后恶心呕吐(PONV)的作用。方法方便选取医院2017年1月—2018年4月期间诊治的择期行全身麻醉子宫切除术患者64例,按随机双盲法予以分组:A组(n=32)术前给与托烷司琼5 mg,B组(n=32)术前给予托烷司琼2 mg、氟哌利多1.25 mg、地塞米松10 mg;术后随访24 h,就2组患者术后PONV、不良反应发生情况进行统计学分析。结果 (1)A组患者术后PONV发生率31.25%高于B组的9.38%(χ2=4.730,P=0.030);(2)A组患者不良反应发生率31.25%高于B组的3.13%(χ2=8.892,P=0.003)。结论托烷司琼复合氟哌利多、地塞米松方案在预防全麻子宫切除术后PONV方面有积极作用,值得借鉴。

Objective To investigate the effect of tropisetron combined with droperidol and dexamethasone on prevention of nausea and vomiting (PONV) after general anesthesia. Methods 64 patients undergoing elective general anesthesia hysterectomy from January 2017 to April 2018 were convenient enrolled in the hospital. They were randomized by double-blind method: group A (n=32) was given tropisetron 5 mg before operation. Group B (n=32) received 2 mg of tropisetron, 1.25 mg of droperidol and 10 mg of dexamethasone. The postoperative follow-up of 24 hours showed statistical analysis of postoperative PONV and adverse reactions in the two groups. Results 1.The incidence of postoperative PONV in group A was 31.25% higher than that in group B 9.38%(χ^2=4.730, P=0.030). 2.The incidence of adverse reactions in group A was 31.25% higher than 3.13% in group B (χ^2=8.892, P=0.003). Conclusion The tropisetron-conjugated droperidol and dexamethasone regimen have a positive effect in preventing PONV after general anesthesia and are worthy of reference.