不同ARB类药物对CHD患者的抗炎、调脂水平的差异性探究

Study on the difference of anti-inflammatory and lipid regulating of different ARB drugs in CHD patients

目的:探讨临床上常用ARB类药物对冠心病(Coronary heart disease,CHD)患者的抗炎及调脂水平差异。方法:入选确诊冠心病(CHD)患者135例,随机分为缬沙坦组、厄贝沙坦组及替米沙坦组,观察各组治疗前及治疗1个月后的血浆Cox-2、TNF-a及胆固醇(TC)及甘油三酯(TG)水平。结果:缬沙坦及替米沙坦组治疗前后的炎症因子Cox-2、TNF-a水平表达具有统计学差异(P<0.05)。厄贝沙坦组治疗前后的炎症因子Cox-2水平表达具有统计学差异(P<0.05),但TNF-a水平表达无统计学差异。缬沙坦组治疗前后的TC、TG水平表达具有统计学差异(P<0.05)。厄贝沙坦组及替米沙坦组治疗前后的TC水平表达具有统计学差异(P<0.05),但TG水平无统计学差异。结论:缬沙坦、厄贝沙坦及替米沙坦均在一定程度上具有减少炎症因子释放,降低血脂(包括TC、TG)水平的作用,但各具特点。

Objective:To investigate the anti-inflammatory and lipid regulating effects of Angiotensin Receptor Blocker(ARB)drugs commonly used in clinical practice on coronary heart disease.Methods:A total of 135 patients with coronary heart disease(CHD)were randomly divided into valsartan group,irbesartan group and telmisartan group.The levels of plasma Cox-2,TNF-a,cholesterol and triglyceride were observed before treatment and one months after treatment.Results:There were significant differences in the levels of inflammatory factors Cox-2 and TNF-a before and after treatment in valsartan and telmisartan groups(P<0.05).There was significant difference in the level of inflammatory factor Cox-2 before and after treatment in irbesartan group(P<0.05),but there was no significant difference in the expression of TNF-a.The expression of TC and TG in valsartan group before and after treatment had statistical difference(P<0.05).There was significant difference in the level of TC between irbesartan group and telmisartan group before and after treatment(P<0.05),but there was no significant difference in TG level between the two groups.Conclusion:Valsartan,irbesartan and telmisartan can reduce the release of inflammatory factors and decrease the levels of lipids(including TC and TG)to some extent,but each has its own characteristics.