生物基质中芬太尼类物质分析方法研究进展

Advances in the Determination of Fentanyl in Biological Matrix

芬太尼是一种有效的麻醉性镇痛药,用于治疗癌症疼痛和其他慢性疼痛以及手术麻醉。从20世纪80年代开始,出现了芬太尼类似物的秘密和非法合成事件,而且新型芬太尼类似物不断出现,这对公众健康和安全构成重大威胁。由于不同芬太尼类物质作用效力不同,生物体内含量相差较大,因此建立可靠稳定的分析方法至关重要。目前已报道的芬太尼及其类似物的分析方法有免疫分析法,气相色谱-质谱联用(GC-MS)、液相色谱-质谱联用(LC-MS)等。结合近年研究,综述了芬太尼类物质的代谢、样品处理方法、分析检测方法等。

Fentanyl,a potent narcotic analgesic,is used in the treatment of cancer pain and other chronic pain,and in surgical anaesthesia.Since 1980s,there have been incidents of clandestine and illicit synthesis of analogues of fentanyl.Novel drugs continue to appear,making a significant threat to public health and safety.Due to the different potency,the contents of fentanyl analogues vary significantly.Therefore,it is essential to establish reliable and stable analytical methods.Several methods have been reported for the detection of fentanyl and its analogues,such as immunoassay techniques,gas chromatography-mass spectrometry(GC/MS)and liquid chromatography-mass spectrometry(LC-MS).In this paper,recent researches on the metabolism,pretreatment and analytical methods of fentanyl were reviewed.