肿瘤相关巨噬细胞在癌症治疗的潜在靶点中的探讨

The role of tumor-associated macrophages in the potential target of cancer therapy

肿瘤的微环境(TME)由肿瘤细胞和周围基质组成,其中巨噬细胞能够促进肿瘤的增殖、侵袭和转移,促进肿瘤血管生成,抑制T细胞介导的抗肿瘤免疫反应,从而导致肿瘤的发生发展。本文阐述了巨噬细胞的形成,从根源上阐述了TAMs如何被用作癌症的治疗靶点,及肿瘤相关巨噬细胞的靶向治疗的抗癌药物的作用机制。以肿瘤相关巨噬细胞(TAMs)表面的标记物作为治疗的靶点或作为抗癌药物的载体进入肿瘤细胞是肿瘤治疗的潜在方法。

The microenvironment(TME) of tumors is composed of tumor cells and surrounding stroma. Macrophages can promote tumor proliferation, invasion and metastasis, promote tumor angiogenesis, and inhibit T cell-mediated anti-tumor immune response, resulting in the occurrence and development of tumors. This article describes the formation of macrophages, describes how TAMs are used as therapeutic targets for cancer from the roots, and reviews the mechanism of anticancer drugs targeted by tumor-associated macrophages. Choosing markers on the surface of tumor-associated macrophages (TAMs) as a therapeutic target or as a carrier of anticancer drugs into tumor cells is a potential method for tumor therapy.