淋巴细胞主动免疫治疗对复发性流产患者BA水平及妊娠结局的影响

Effect of Lymphocyte Active Immunotherapy on BA Level and Pregnancy Outcome in Patients with Recurrent Spontaneous Abortion

目的:探究淋巴细胞主动免疫治疗(LIT)对复发性流产(RSA)患者BA水平及妊娠结局的影响。方法:选取某院收治的102例RSA患者作为研究对象,按数字随机法分为观察组53例和对照组49例,全组患者均接受常规保胎治疗,观察组在常规保胎治疗基础上接受配偶或第三方外周血LIT治疗,比较两组患者治疗前后BA水平变化及妊娠结局的差异。结果:治疗后,观察组CD3+BE、CD4+BE、CD8+BE、IL-4、IL-10水平明显高于对照组,TNF-α、INF-γ水平明显低于对照组(P<0.05);观察组治疗成功率明显高于对照组(P<0.05)。结论:LIT治疗RSA患者疗效显著,提高患者成功妊娠率。

Objective:To investigate the effect of LIT on BA level and pregnancy outcome in patients with RSA.Methods:102 patients with RSA admitted in a hospital were divided into observation group(53 cases)and control group(49 cases).Both two groups were given routine fetal protection,while the observation group was added peripheral blood LIT.The changes of BA levels and the pregnancy outcomes after treatment were observed.Results:After treatment,the levels of CD3^+BE,CD4^+BE,CD8^+BE,IL-4 and IL-10 in the observation group were significantly higher than those in the control group,while the levels of TNF-αand INF-γin the observation group were significantly lower than those in the control group(P<0.05).The success rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).Conclusion:The efficacy of LIT in the treatment of RSA patients is significant and it can improve the successful pregnancy rate.