理气清肠方加减治疗溃疡性结肠炎疗效观察

Clinical observation on the therapy of Liqi Qingchang Decoction on ulcerative colitis

目的探讨理气清肠方加减治疗溃疡性结肠炎的临床疗效。方法将63例溃疡结肠炎患者随机分为治疗组32例,对照组31例。对照组采用西药美沙拉嗪肠溶片口服治疗,每次1 g,每日4次,疗程4周;治疗组采用以理气健脾化瘀清肠法为治则的理气清肠方加减口服及保留灌肠治疗,每日2次,疗程4周。比较2组患者治疗前后的排便次数、便血情况、腹痛情况、IBDQ量表评分等情况及临床有效率、诱导缓解率。结果 2组患者治疗后的排便次数,便血、腹痛等症状评分,以及IBDQ评分均较治疗前明显改善(P均<0. 05);治疗组治疗后的相关症状评分较对照组改善更为明显(P均<0. 05)。治疗组的临床治疗有效率及诱导缓解率明显高于对照组(P <0. 05)。结论理气清肠方治疗溃疡性结肠炎能改善患者的临床症状,促进肠道病变黏膜的愈合,提高患者的生活质量。

Objective It is to investigate the clinical efficacy of the therapy of Liqi Qingchang Decoction on ulcerative colitis.Methods Totally 63 patients with ulcerative colitis were selected and randomly divided into treatment group(n=32)and control group(n=31).The patients in the control group were treated with mesalazin enteric-coated tablets by oral administration,1g/time,4 times/day,for 4 weeks.the patients in the treatment group were treated with Liqi Qingchang Decoction,which therapeutic principle was based on regulating Qi and strengthening spleen-transform stasis and cleaning intestine,the traditional Chinese medicine decoction was given by retention enema as well as oral administration,2 times/day,for 4 weeks.The stool frequency,bloody stools,abdominal pain and IBDQ scale scores before and after treatment,clinical efficiency and the rate of induced remission were compared between the two groups.Results The scores of stool frequency,symptom scores of bloody stools and abdominal pain,and scores of IBDQ scale of the two groups were all improved significantly after treatment(P<0.05),but the improvements of the symptoms in the treatment group were significantly better than those in the control group.The total effectiveness rate and the rate of induced remission in the treatment group were significantly higher than that in the control group(P<0.05).Conclusion Liqi Qingchang Decoction can significantly improve the clinical symptoms,promote the healing quality of intestinal mucosa,and improve patients’s quality of life in the treatment of ulcerative colitis.