山椒素药理学研究进展

Advances in pharmacological research of sanshool

中药花椒为芸香科花椒属植物的果皮,具有止痒、止痛、杀虫等功效。近年来研究发现,山椒素作为花椒中主要的生物活性成分,能够与多种离子通道和受体结合,发挥广泛的生物学效应,起到麻醉镇痛、肠道保护、降血糖等作用。该文主要从药代动力学、药物靶点及药理作用三方面进行综述,以期为山椒素的系统研究及新药开发提供参考。

The pericarp of Zanthoxylum bungeanum Maxim.(Rutaceae) is a traditional Chinese herbal medicine with many therapeutic effects such as antipruritic,analgesic and insecticidal effects. In recent years,various studies have revealed sanshool as the main bioactive ingredient of Zanthoxylum bungeanum Maxim. It can bind to a variety of ion channels and receptors,exerting wide-ranging biological and pharmacological activities including analgesic effects,intestinal protection,hypoglycemic effects and other effects. The relevant pharmacokinetics,drug targets and pharmacological effects were reviewed in this paper to provide a reference for the systematic research of sanshool and the development of new drugs.