MLLT10在肝细胞肝癌中的表达及临床意义

Expression of MLLT10 in hepatocellular carcinoma and its clinical significance

目的探讨MLLT10的表达水平在肝细胞肝癌(HCC)中的表达及临床意义。方法利用癌症基因组图谱(TCGA)数据库对MLLT10在HCC癌组织及癌旁正常组织中的表达水平进行分析,分析MLLT10的表达水平与HCC患者的年龄、性别、血清甲胎蛋白(AFP)、肿瘤TNM分期、病理分级、整体生存率和无进展生存率的关系。结果 MLLT10在HCC癌组织中的表达水平高于癌旁正常组织,差异有统计学意义(P<0.05)。性别、肿瘤TNM分期和病理分级与HCC癌组织MLLT10的表达水平有关(P<0.05)。年龄和血清AFP水平与HCC癌组织MLLT10的表达水平无关(P>0.05)。MLLT10高水平表达HCC患者的整体生存率和无进展生存率均低于MLLT10低水平表达者,差异有统计学意义(均P<0.05)。结论 MLLT10可能参与HCC的发生和发展,有望成为检测HCC的肿瘤标志物和预后判断因子。

Objective To explore the expression of MLLT10 in hepatocellular carcinoma (HCC) and its clinical significance. Methods The cancer genome atlas (TCGA) database was used to analyze the expression of MLLT10 in HCC cancer tissues and normal tissue adjacent to cancer. The relationship between the expression of MLLT10 and age, sex, serum alpha-fetoprotein(AFP), tumor TNM stage, pathological grade, overall survival rate and progression-free survival rate of HCC patients was analyzed. Results The level of MLLT10 in tissues of HCC was higher than that in normal tissues adjacent to HCC, and the difference was statistically significant ( P < 0.05). The gender, tumor TNM stage and pathological grade were correlated with the level of MLLT10 in HCC tissues ( P < 0.05), and the age and AFP were not correlated with MLLT10 expression in HCC tissues ( P > 0.05). The overall survival rate and progression-free survival rate of HCC patients with high level of MLLT10 were lower than those with low level of MLLT10, and the differences were statistically significant (all P < 0.05). Conclusion MLLT10 may be involved in the occurrence and development of HCC, and is expected to be a tumor marker and prognostic factor for detection of HCC.