T细胞亚群与ANCA相关性小血管炎研究进展

The Research Advances of T Lymphocyte Subsets and ANCA-associated Vasculitis

抗中性粒细胞胞浆抗体(ANCA)相关性小血管炎(AAV)是一种以全身多系统小血管炎症和纤维素样坏死为主要特征的自身免疫性疾病。ANCA作为自身抗体,分别针对蛋白酶-3(PR3)和髓过氧化物酶(MPO)两种靶抗原在AAV过程中起重要作用。T细胞亚群与ANCA有较多参与和相互作用,也是AAV的关键致病因子,但其作用的具体机制尚不完全清楚。本文综述部分T细胞亚群与AAV的研究进展。

Anti-neutrophil cytoplasmic antibodies(ANCA)associated vasculitis(AAV)is an autoimmune disease characterized by systemic small vessel inflammation and cellulose-like necrosis.As an autoantibody,ANCA plays an important role in AAV process by targeting protease-3(PR3)and myeloperoxidase(MPO)target antigens.T lymphocyte subsets and ANCA have more involvement and interaction,and are also the key pathogenic factors of AAV,but the specific mechanism of their role is not yet fully clear.This article reviews the research progress of T cell subsets and ANCA-associated vasculitis.