针刺配合中药治疗肝郁脾虚型慢性疲劳综合征疗效观察

Therapeutic Observation of Acupuncture plus Chinese Medication for Chronic Fatigue Syndrome Due to Liver-depression and Spleen-deficiency

目的观察针刺背俞穴配合解郁健脾通经汤治疗肝郁脾虚型慢性疲劳综合征临床疗效。方法 86例肝郁脾虚型慢性疲劳综合征患者随机分为治疗组和对照组,每组43例。对照组采用口服解郁健脾通经汤治疗,治疗组在对照组基础上给予针刺背俞穴治疗。观察两组治疗前后临床症状分级量化积分、焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分、T淋巴细胞亚群水平、血清白细胞介素-2(IL-2)与干扰素-?(IFN-?)水平变化,并比较两组临床疗效。结果治疗组总有效率为90.7%,高于对照组的72.1%(P<0.05)。两组治疗后临床症状分级量化积分、SAS评分、SDS评分均低于同组治疗前(P<0.05),治疗组低于对照组(P<0.05)。两组治疗后CD3﹢、CD4﹢、CD4﹢/CD8﹢测定值均高于同组治疗前(P<0.05),治疗组高于对照组(P<0.05)。两组治疗后血清IL-2、IFN-?水平均高于同组治疗前(P<0.05),治疗组高于对照组(P<0.05)。结论肝郁脾虚型慢性疲劳综合征患者采取针刺背俞穴配合解郁健脾通经汤进行治疗,可显著提高临床疗效,明显降低患者焦虑、抑郁程度,并可有效调节T淋巴细胞亚群、血清IL-2与IFN-?水平。

Objective To observe the clinical efficacy of acupuncture at back-Shu points plus Jieyu Jianpi Tongjing decoction (a formula for anti-depression, reinforcing spleen and unblocking meridians) in treating chronic fatigue syndrome due to liver-depression and spleen-deficiency. Method Eighty-six patients with chronic fatigue syndrome due to liver-depression and spleen-deficiency were randomized into a treatment group and a control group, with 43 cases in each group. The control group was intervened by oral administration of Jieyu Jianpi Tongjing decoction, while the treatment group was additionally given acupuncture at back-Shu points. The two groups were observed before and after treatment to measure changes in the scores of clinical symptom grading quantification, Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS), and the levels of T-lymphocyte subsets, and interleukin (IL)-2 and interferon (IFN)–γ in serum. The clinical efficacies of the two groups were also compared. Result The total effective rate was 90.7% in the treatment group, significantly higher than 72.1% in the control group (P<0.05). The clinical symptom grading quantification score and the scores of SAS and SDS dropped after treatment in both groups (P<0.05), and the treatment group was lower than the control group (P<0.05). The levels of CD3^﹢, CD4^﹢ and CD4^﹢/CD8^﹢ increased after treatment in the two groups (P<0.05), and the treatment group was higher than the control group (P< 0.05). The levels of IL-2 and IFN–γ in serum increased after treatment in the two groups (P<0.05), and the treatment group was higher than the control group (P<0.05). Conclusion Acupuncture at back-Shu points plus Jieyu Jianpi Tongjing decoction can significantly improve the clinical efficacy in treating patients with chronic fatigue syndrome due to liver-depression and spleen deficiency. It can obviously mitigate anxiety and depression, and effectively regulate the levels of T-lymphocyte subsets, and IL-2 and IFN-γ in serum.