针刺预防产妇卡前列素氨丁三醇不良反应临床观察

Clinical Observation of Acupuncture in Preventing Adverse Reactions Caused by Carboprost Tromethamine in Delivery Women

目的观察针刺对自然分娩产妇使用卡前列素氨丁三醇注射液所引起的不良反应的防治作用。方法使用卡前列素氨丁三醇注射液的自然分娩产妇60例,随机分为针刺组和对照组,每组30例。针刺组给予针刺治疗,对照组不予处理。记录产妇宫体注射卡前列素氨丁三醇注射液时(T_0),注射后5 min(T_1),注射后10 min(T_2),及出产房时(T_3)的血压(BP)、心率(HR)、血氧饱和度(SPO_2),并比较两组不良反应发生率。结果对照组T_1、T_2的收缩压(SBP)、舒张压(DBP)、HR明显高于T_0,差异有统计学意义(P<0.05);针刺组各时刻比较,差异无统计学意义(P>0.05)。针刺组呕吐、胸闷、腹泻的发生率低于对照组,差异有统计学意义(P<0.05);两组恶心和颜面潮红的发生率比较,差异无统计学意义(P>0.05)。结论针刺可以有效地缓解自然分娩产妇因使用卡前列素氨丁三醇注射液所引起的不良反应,产妇循环更平稳。

Objective To observe the preventive and treatment effect of acupuncture on the adverse reactions caused by carboprost tromethamine injection in natural delivery women. Method Sixty natural delivery women who had used carboprost tromethamine injection were randomized into an acupuncture group and a control group, with 30 cases in each group. The acupuncture group was intervened by acupuncture treatment, while the control group was by no treatment. Blood pressure (BP), heart rate (HR) and oxygen saturation (SPO2) were recorded at the intrauterine injection of carboprost tromethamine injection (T0), 5 min later (T1) and 10 min later (T2), as well as at leaving birthing room (T3). The occurrence rates of adverse reactions of the two groups were compared. Result In the control group, the systolic blood pressure (SBP), diastolic blood pressure (DBP) and HR at T1 and T2 were significantly higher than those at T0 (P<0.05);there were no significant differences among the records at different time points in the acupuncture group (P>0.05). The occurrence rates of vomiting, chest stuffiness and diarrhea in the acupuncture group were lower than those in the control group, and the differences were statistically significant (P<0.05);there were no significant differences in the occurrence rates of nausea and flush between the two groups (P>0.05). Conclusion Acupuncture can effectively mitigate the adverse reactions caused by carboprost tromethamine injection in natural delivery women and maintain a more stable circulatory system.