三七通舒胶囊联合rt-PA对CI患者脑电图和神经功能的影响

Effects of Sanqi Tongshu Capsule and rt-PA on EEG and neurological function in patients with CI

目的探究三七通舒胶囊联合重组人组织型纤溶酶原激活剂(rt-PA)溶栓治疗脑梗死(CI)对CI脑电图和神经功能的影响。方法将124例CI患者随机均分为联合组与参照组,皆行CI常规治疗,此外参照组予以rt-PA静脉溶栓治疗,联合组在参照组基础之上加用三七通舒胶囊治疗。比较治疗前及治疗4 w后两组脑电图参数[大脑对称指数(BSI)、δ+θ波与α+β波功率比率(DTABR)]、神经功能[改良爱丁堡-斯堪的纳维亚卒中评分量表(MESSS)]、生活质量[卒中影响量表(SIS)]变化。结果治疗4 w后,两组脑电图BSI、DTABR及MESSS评分皆较治疗前大幅降低,SIS评分较治疗前大幅上升,且联合组改善幅度均显著大于参照组(P <0.05);联合组治疗的中医症候有效率明显高于参照组(P <0.05)。结论三七通舒胶囊联合rt-PA溶栓治疗,可有效改善脑CI患者脑电图异常表现及神经功能,提高患者生活质量,治疗效果更好,有利于患者预后康复。

Objective To explore the effects of Sanqi Tongshu Capsule combined with recombinant human tissue plasminogen activator(rt-PA)thrombolysis on the electroencephalogram(EEG)and neurological function of cerebral infarction(CI).Me&ods A total of 124 patients with CI were randomly divided into a combined group and a control group.All patients were treated with routine therapy for CI.The control group was treated with rt-PA intravenous thrombolysis additionally,and the combined group was treated with Sanqi Tongshu Capsule on the basis of the control group.The changes of EEG parameters[BSI,andδ+θwave andα+βwave(DTABR)],neurological function[Modified Edinburgh-Scandinavian Stroke Scale(MESSS)]and quality of life[Stroke Impact Scale(SIS)]before and after four weeks of treatment were compared between the two groups.Results After four weeks of treatment,the EEG BSI,DTABR and MESSS scores in the two groups were significantly lower than those before the treatment,the SIS scores were significantly higher than those before the treatment,and the improvement degree in the combined group was significantly greater than that in the control group(P<0.05);the effective rate of TCM symptoms in the combined group was significantly higher than that in the control group(P<0.05).Conclusion Sanqi Tongshu Capsule combined with rt-PA thrombolysis therapy can effectively improve the abnormal EEG and neurological function of patients with cerebral CI,improve the quality of life of patients,and have better therapeutic effect,which is conducive to the prognosis and rehabilitation of patients.