探讨硫酸沙丁胺醇联合布地奈德雾化吸入治疗哮喘疗效及对呼吸道症状的影响

To investigate the curative effect of salbutamol sulfate combined with budesonide aerosol inhalation in the treatment of asthma and the influence on respiratory symptoms

目的探讨硫酸沙丁胺醇联合布地奈德雾化吸入治疗哮喘疗效及对呼吸道症状的影响。方法 83例哮喘患者根据治疗方案不同分为A组45例、B组38例,均实施常规干预,A组给予硫酸沙丁胺醇联合布地奈德雾化吸入,B组单给予布地奈德雾化吸入治疗,均连续治疗14 d。评估治疗疗效、呼吸道症状严重程度,记录呼吸道症状缓解时间,并进行肺功能指标、血清炎症因子检测。结果 A组本次治疗总有效率为93.33%,显著高于B组的76.32%,差异有统计学意义(P<0.05)。两组治疗前呼吸道症状评分比较差异无统计学意义,治疗后各项呼吸道症状评分均较治疗前显著下降(P<0.05),但与B组相比,A组喘息、咳嗽、呼吸困难、肺内哮鸣音评分降幅明显大,且喘息、咳嗽、呼吸困难、肺内哮鸣音缓解时间显著短(P<0.05)。两组治疗前表征肺功能指标及血清及炎症因子水平比较无统计学意义,但治疗后与B组相比,A组用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、最大呼气流量(PEF)及血清抗炎因子白细胞介素(IL)-4均明显升高,细胞免疫因子干扰素(IFN)-γ明显下降(P<0.05)。结论硫酸沙丁胺醇联合布地奈德雾化吸入治疗哮喘的临床疗效优于单纯布地奈德雾化吸入治疗,且对改善患者呼吸道症状、肺功能及减轻炎症反应有突出效果。

Objective To investigate the curative effect of salbutamol sulfate combined with budesonide aerosol inhalation in the treatment of asthma and the influence on respiratory symptoms.Methods 83 patients with asthma were divided into the A group(45 cases)and the B group(38 cases)according to different regimens,and all the patients were given routine intervention.The A group were given salbutamol sulfate combined with budesonide aerosol inhalation whilethe B group were treated with budesonide aerosol inhalation alone.All patients were treated for 14 days.The therapeutic effects and severity of respiratory symptoms were evaluated,and the remission time of respiratory symptoms was recorded.Pulmonary function indexes and serum inflammatory factors were detected.Results The total response rate of the A group was significantly higher than that of the B group(93.33%vs 76.32%)(P<0.05)but there was no significant difference between the two groups in scores of respiratory tract symptoms before the treatment.After the treatment,scores of respiratory tract symptoms were decreased significantly(P<0.05),but compared with the B group,the decrease of scores of wheezing,cough,dyspnea and pulmonary wheezing was obviously greater,and the remission time of above symptoms was significantly shorter in the A group(P<0.05).There were no statistically significant differences of pulmonary function indexes and serum levels of inflammatory factors between the two groups before treatment.After treatment,the forced vital capacity(FVC),forced expiratory volume in 1s(FEV1),peak expiratory flow(PEF)and serum anti-inflammatory factor(interleukin IL-4)in the A group were significantly higher than and cell immune factor interferonγ(IFN-γ)was significantly lower than those in the B group(P<0.05).Conclusion The clinical curative effect of salbutamol sulfate combined with budesonide aerosol inhalation is better than that of budesonide aerosol inhalation alone in the treatment of asthma.Besides,effects of combined use are obvious in relieving respiratory symptoms,improving lung function and reducing inflammatory response.