哌拉西林舒巴坦钠对细菌性肺炎患儿血清CRP及ESR水平的影响分析

Effect of piperacillin sulbactam sodium on serum CRP and ESR levels in children with bacterial pneumonia

目的探究哌拉西林舒巴坦钠对细菌性肺炎患儿血清C反应蛋白(CRP)、红细胞沉降率(ESR)水平的影响。方法选取2016年2月至2018年2月本院收治的细菌性肺炎患儿96例,采用随机数字表法分为观察组与对照组各48例,两组患者均予以常规退热、止咳、雾化等对症治疗,对照组在此基础上予以单一阿奇霉素治疗,观察组采用阿奇霉素联合哌拉西林舒巴坦钠治疗,观察两组患者治疗有效率,治疗后发热、咳嗽等临床症状恢复时间及住院时间,治疗前后血清CRP、ESR水平,治疗过程中不良反应发生情况。结果两组患儿治疗有效率分别为95.83%与83.33%,观察组治疗有效率明显高于对照组(P<0.05);观察组与对照组患儿发热、咳嗽、啰音、肺部阴影等临床症状恢复时间及住院时间比较均明显缩短(P<0.05);两组患儿治疗前血清CRP、ESR水平差异均无统计学意义,治疗后两组患儿血清CRP、ESR水平均明显低于治疗前(P<0.05),且观察组明显低于对照组(P<0.05);两组患儿治疗过程中不良反应发生率分别为8.33%与4.17%,观察组与治疗组之间患儿不良反应发生率差异无统计学意义。结论哌拉西林舒巴坦钠治疗小儿细菌性肺炎疗效确切,安全性高,可迅速缓解患儿临床症状及体征,明显缩短住院时间,有效抑制炎性反应的发生。

Objective To explore the effect of piperacillin sulbactam sodium on serum C reactive protein(CRP)and erythrocyte sedimentation rate(ESR)in children with bacterial pneumonia.Methods 96 children with bacterial pneumonia admitted in our hospital from February 2016 to February 2018 were divided into the observation group and the control group with 48 cases.The two groups were treated with routine antipyretic,cough and atomization treatment.The control group was treated with single azithromycin on the basis of the control group,and the observation group was treated with azithromycin.Combined with piperacillin sulbactam sodium,the treatment of two groups was effective,the recovery time of fever,cough and other clinical symptoms after treatment,the level of serum CRP and ESR before and after treatment,and the occurrence of adverse reactions during the treatment.Results The effective rate of treatment in the two groups was 95.83%and 83.33%,respectively.The effective rate of treatment in the observation group was significantly higher than that of the control group(P<0.05).The recovery time and hospitalization time of fever,cough,rale,lung shadow and other clinical symptoms were significantly shortened(P<0.05)in the observation group and the control group(P<0.05),and the serum CRP before treatment in the group of children.There was no significant difference in the level of ESR.The serum levels of CRP and ESR in the two groups were significantly lower than those before treatment(P<0.05),and the observation group was significantly lower than that of the control group(P<0.05).The incidence of adverse reactions in the two groups was 8.33%and 4.17%,respectively.There was no significant difference in the rate of occurrence.Conclusion Piperacillin sulbactam sodium is effective and safe in the treatment of children's bacterial pneumonia.It can quickly relieve the clinical symptoms and signs of children,shorten the time of hospitalization and effectively inhibit the occurrence of inflammatory reaction.