脾氨肽联合维生素A、E治疗反复性呼吸道感染患儿的临床效果及其对免疫功能的影响

Efficacy of Spleen Aminopeptide Combined with Vitamin A and E in the Treatment of Children with Recurrent Respiratory Tract Infection and its Immune Function

目的探究脾氨肽联合维生素A、E治疗反复性呼吸道感染患儿的临床效果及其对免疫功能的影响。方法选取我院2016年12月—2018年1月收治的反复性呼吸道感染患儿130例,按照随机数字表法分为观察组(n=67)和对照组(n=63)。两组在急性感染期均予抗感染、退热、止咳、加强营养等常规治疗,同时对照组联合维生素A、E治疗;在对照组基础上,观察组加用脾氨肽口服液。两组均治疗2个月。观察临床疗效,检测T淋巴细胞亚群、免疫球蛋白水平变化,记录不良反应发生情况。结果观察组、对照组临床总有效率分别为91.04%(61/67)、73.02%(46/63),差异有统计学意义(χ~2=7.239,P=0.013)。与本组治疗前比较,观察组治疗后CD3+、CD4+、CD4+/CD8+、IgG、IgM及IgE水平升高,CD8+水平降低,差异有统计学意义(P<0.05);与对照组比较,观察组治疗后CD3+、CD4+、CD4+/CD8+、IgG、IgM及IgE水平明显升高,CD8+水平显著降低,差异有统计学意义(P<0.01)。两组治疗期间均未出现明显不良反应。结论脾氨肽联合维生素A、E治疗反复性呼吸道感染患儿可有效提高临床疗效,增强机体免疫力,有利于预后。

ObjectiveTo explore the clinical effect of spleen aminopeptide combined with vitamin A and E and their effect on the immune function of children with recurrent respiratory tract infection (RRTI). MethodsA total of 130 children with RRTI admitted to our hospital from December 2016 to January 2018 were randomly divided into observation group ( n =67) and control group ( n =63). Both groups were given conventional treatment such as anti-infection, abatement of fever, cough relief and nutrition enhancement during acute infection. In the meantime, the control group was treated with vitamin A and E. On the basis of the control group, the observation group was supplemented with Spleen Aminopeptide Oral Solution. Both groups were treated for 2 months. The clinical efficacy was observed, and the changes of T lymphocyte subsets and immunoglobulin levels were detected. In addition, the occurrence of adverse reactions was recorded. ResultsThe total clinical effective rates of the observation group and the control group were 91.04%(61/67) and 73.02%(46/63) respectively, and the difference was statistically significant (χ 2=7.239, P =0.013). Compared with those before treatment, the levels of CD3^+, CD4^+, CD4^+/ CD8^+, IgG, IgM and IgE in the observation group were increased while the levels of CD8^+ were decreased significantly after treatment ( P <0.05). Compared with the control group, the levels of CD3^+, CD4^+, CD4^+/CD8^+, IgG, IgM and IgE in the observation group were increased significantly and the levels of CD8^+ were decreased significantly after treatment ( P <0.01). There were no obvious adverse reactions during the treatment. ConclusionSpleen aminopeptide combined with vitamin A and E in the treatment of children with RRTI can effectively improve the clinical efficacy and the body's immunity, which is, therefore, conducive to the prognosis of children.