不同胎龄早产儿生后7天内网织红细胞血红蛋白含量变化趋势

Trend of reticulocyte hemoglobin content in preterm infants with different gestational ages in 7 days after birth

目的建立不同胎龄早产儿网织红细胞血红蛋白含量(Ret-He)的参考值范围,并且评估生后7天内Ret-He的变化趋势。方法测量不同胎龄早产儿在生后24小时、2～3天、7天的Ret-He值,并分析Ret-He值与胎龄的相关性。结果纳入699例早产儿,采集1 286份血样本。生后24小时内(n=699,r=0.126,P=0.002)、2～3天(n=440,r=0.487,P<0. 001)、7天(n=147,r=0. 510,P<0. 001)Ret-He水平与胎龄呈正相关,日龄越大相关性越强。147例早产儿在生后24小时内、2～3天、7天的平均Ret-He分别为32.18、27.82、28.85 pg。不同胎龄早产儿2～3天的Ret-He水平均低于24小时内,差异有统计学意义(P<0.001);生后2～3天至生后7天的Ret-He存在轻度上升趋势,其中胎龄30～33周早产儿生后7天的Ret-He高于生后2～3天,差异有统计学意义(P<0. 001)。结论 Ret-He与胎龄存在弱的相关性,其在生后2～3天内显著下降,出生2～3天的Ret-He水平更能真实反映机体铁水平。

Objective To establish the reference range of reticulocyte hemoglobin content (Ret-He) in premature infants with different gestational ages (GA), and to evaluate the trend of change in Ret-He within 7 days after birth. Method The Ret-He values of premature infants with different gestational ages were measured at 24 hours, 2-3 days and 7 days after birth, and the correlation between Ret-He values and gestational age was analyzed. Results A total of 1286 blood samples were collected from 699 premature infants. Gestational age was positively correlated with Ret-He levels at 24 hours ( n =699, r =0.126, P =0.002), 2-3 days ( n =440, r =0.487, P <0.001) and 7 days ( n =147, r =0.510, P <0.001) after birth. The correlation was increased over the age. The average Ret-He levels of 147 premature infants at 24 hours, 2-3 days and 7 days after birth were 32.18, 27.82 and 28.85 pg respectively The Ret-He levels at 2-3 days after birth in preterm infants with different gestational ages were lower than those at 24 hours, and there was statistically difference ( P <0.001). The Ret-He levels increased slightly from 2-3 days to 7 days after birth. The Ret-He levels at the 7th day after birth was higher than that at 2-3 days in preterm infants with gestational age of 30-33 weeks, and there was statistically difference ( P <0.001). Conclusion Ret-He was weakly correlated with gestational age and it is decreased significantly in 2-3 days after birth. The Ret-He level at 2-3 days after birth reflects the body's iron level more accurately.