川芎嗪对终末期糖尿病肾病患者微炎症及营养不良的影响

Effect of Ligustrazine on microinflammation and malnutrition in patients with end-stage diabetic nephropathy

目的:探讨川芎嗪对终末期糖尿病肾病(DN)患者微炎症及营养不良的影响。方法:收治行血液透析DN患者60例,随机平分两组。对照组采取常规的血液透析治疗,治疗组在血液透析治疗的基础上加用川芎嗪注射液静脉滴注,疗程均14 d。分别于治疗前和治疗后检测两组患者的血红蛋白(HB)、血浆总蛋白(TP)、白蛋白(ALB)、转铁蛋白水平(TRF)、营养不良-炎症评分(MIS)等营养指标以及高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素1(IL-1)等炎症指标。结果:经过2周的治疗,治疗组hs-CRP、TNF-α、IL-1水平及MIS评分明显下降,HB、ALB、TRF水平升高,与对照组比较差异有统计学意义(P<0.05)。结论:川芎嗪注射液通过降低终末期DN患者hs-CRP、TNF-α、IL-1水平,可以有效改善患者微炎症及营养不良的状态。

Objective:To investigate the effects of Ligustrazine on the micro-inflammatory and malnutrition state in patients with end-stage diabetic nephropathy.Methods:60 patients with diabetic nephropathy undergoing hemodialysis were randomly divided into the two groups on average.Patients in control group were treated by conventional hemodialysis,while patients in the treatment group were treated by hemodialysis and ligustrazine.The nutritional indicators such as hemoglobin(HB),total plasma protein(TP), albumin(ALB),transferrin(TRF),malnutrition-inflammation score(MIS)and inflammatory markers such as high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-alpha(TNF-alpha),interleukin-1(IL-1)were measured before and after treatment.Results:After the therapies,the levels of hs-CRP,TNF-α,IL-1 and MIS were significantly lower,and the levels of HB, ALB and TRF were higher in the treatment group,compared with the control group,the difference was statistically significant(P<0.05).Conclusion:Ligustrazine can remarkably decrease the levels of serum hs-CRP,TNF-α and IL-1,and ameliorate the micro-inflammatory and malnutrition state in patients with end-stage diabetic nephropathy.