小儿皮肤屏障功能与咳嗽变异性哮喘的关系研究

A study of relationship between skin barrier function and cough variant asthma in children

目的:探讨咳嗽变异型哮喘(CVA)患儿与健康儿童皮肤屏障功能的差异性。方法:分别纳入2～7岁缓解期和(或)稳定期CVA患儿和健康儿童各60例。对各组小儿前额和颊前分别进行经表皮水分丢失量(TEWL)、角质层含水量及pH值测量。将所得检测结果建立数据库,采用SPSS 21.0软件进行统计学分析。结果:与健康儿童相比,CVA患儿前额和颊前TEWL均明显高于健康儿童(P <0.05);CVA患儿前额和颊前角质层含水量均明显低于健康儿童(P <0.05);CVA患儿前额和颊前pH值均高于健康儿童(P <0.05)。结论:CVA患儿与健康儿童相比,皮肤屏障功能存在缺陷,通过改善CVA患儿皮肤屏障功能可能是防治CVA的一个措施。

Objective: To study the differentiation on skin barrier function between children with cough variant asthma (CVA) and healthy. Methods: 60 children with CVA and 60 healthy children with the age of 2~7 years old were enrolled. The transepidermal water loss (TEWL), atraum corneum (SC) hydration and pH value were measured. The data was analysed by SPSS 21.0 software. Results: Compare to the healthy children,in the forehead cheek front, TEWL of CVA were significantly higher ( P <0.05). On the forehead and front cheek tested sites, SC hydration of CVA children were distinctly lower than the healthy children ( P < 0.05). Both forehead and front cheek pH values of CVA children were obviously higher than the healthy group ( P <0.05). Conclusion: Improving skin barrier function in children with CVA may be a measure to prevent CVA.