摘要
目的探讨阿托伐他汀钙联合氨氯地平治疗原发性高血压的临床疗效。方法将134例原发性高血压患者按随机数字表法分为对照组和观察组,每组67例。2组均给予氨氯地平片治疗。在此基础上,观察组给予阿托伐他汀钙治疗。观察2组治疗前、治疗4个月后血压[收缩压(SBP)、舒张压(DBP)]和血清白细胞介素-6(IL-6)、C-反应蛋白(CRP)、内皮素(ET)水平的变化及临床疗效。结果观察组总有效率高于对照组(92.54%比79.10%,P<0.05)。观察组治疗4个月后DBP、SBP和血清IL-6、CRP、ET水平均低于对照组(均P<0.05)。结论阿托伐他汀钙联合氨氯地平治疗原发性高血压的临床疗效确切,能够明显降低患者的血压及炎性因子水平,改善血管内皮功能。
Objective To explore the clinical effect of atorvastatin calcium combined with amlodipine on essential hypertension.Methods A total of 134 patients with essential hypertension were randomly treated with amlodipine tablets alone(control group,n=67)or in combination with atorvastatin calcium(observation group,n=67).Systolicblood pressure(SBP),diastolic blood pressure(DBP)and serum levels of interleukin-6(IL-6),C-reactive protein(CRP)and endothelin(ET)were measured before and after treatment for 4 months,and clinical curative effect.Results The total effective rate in observation group was higher than that in control group(92.54% vs 79.10%,P<0.05).After treatment for 4 months,the DBP,SBP and serum levels of IL-6,CRP and ET in observation group were lower than those in control group(P<0.05).Conclusion Atorvastatin calcium combined with amlodipine can significantly reduce blood pressure and inflammatory factors and improve vascular endothelial functionin patients with essential hypertension.
作者
王菊红
WANG Ju-hong(The First Department of Internal Medicine,Jiaozuo Fifth People’s Hospital,Jiaozuo 454000,China)
出处
《实用临床医学(江西)》
CAS
2018年第12期24-26,共3页
Practical Clinical Medicine
关键词
原发性高血压
阿托伐他汀钙
氨氯地平
血压
疗效
essential hypertension
atorvastatin calcium
amlodipine
blood pressure
curative effect