化疗促肿瘤转移的机制研究

Mechanism of chemotherapy-induced tumor metastasis

化疗是恶性肿瘤的主要治疗手段之一,旨在杀灭肿瘤细胞,提高患者生存率。然而新进研究发现,化疗在抗肿瘤的同时也促进肿瘤的远处新增转移,文章将进一步赋予"化疗副作用"新的内涵。另一方面,肿瘤转移是导致患者生存期短的主要因素,抑制化疗所致肿瘤转移是当前应该得到广泛关注的热点。现代研究认为,化疗药物通过诱导肿瘤生物学特征的改变并引起一系列"宿主反应"从而促进肿瘤转移,文章将结合与肿瘤转移相关的"种子?土壤"学说,对化疗促进肿瘤转移的机制进行综述。

Chemotherapy is one of the main treatments for malignant tumors,aiming to kill tumor cells and improve patient survival. However,the new study have found that chemotherapy also promotes distant metastasis of tumors while treating tumor,and the article will give further new meaning to“chemotherapy side effects.”On the other hand,tumor metastasis is the main cause of short-term survival of patients. Inhibition of tumor metastasis caused by chemotherapy is a hot topic that should be widely concerned. Modern research suggests that chemotherapeutic drugs promote tumor metastasis by inducing changes in the biological characteristics of tumors and causing a series of“host reactions”. The article summarizes the mechanisms of chemotherapy-induced tumor metastasis in combination with the seed and soil theory related to tumor metastasis.