Th17及相关细胞因子在肝炎肝硬化患者中的表达变化研究

Expression change of Th17 and related cytokines in patients with hepatitis cirrhosis

目的研究分析Th17及相关细胞因子在肝炎肝硬化患者中的表达变化情况。方法选取2017年7月～2018年2月我院收治的80例肝炎肝硬化患者为观察组,同时期的80例同龄健康体检人员为对照组。检测与比较两组的Th17细胞频率及相关细胞因子[白细胞介素-6(IL-6)、白介素-17(IL-17)、白介素-22(IL-22)及白介素-23(IL-23)]表达水平,并比较观察组中不同Child-Pugh分级及病因者的上述指标表达水平。结果观察组的Th17细胞频率及相关细胞因子表达水平均高于对照组,差异有统计学意义(P <0.05),Child-Pugh分级较高者的表达水平高于分级较低者,差异有统计学意义(P <0.05),不同病因者的表达水平比较,差异无统计学意义(P> 0.05)。结论 Th17及相关细胞因子在肝炎肝硬化患者中的表达显著异常,且肝脏损伤程度对其表达水平有一定影响,应重视肝炎肝硬化患者上述指标的监测。

Objective To analyze the expression change situation of Th17 and related cytokines in patients with hepatitis cirrhosis. Methods 80 patients with hepatic cirrhosis in the hospital from July 2017 to February 2018 were selected as an observation group,and 80 healthy persons with the same age at the same time as a control group.Levels of Th17 cell frequency and related cytokines[interleukin-6(IL-6),interleukin-17(IL-17),interleukin-22(IL-22) and interleukin-23(IL-23)] of two groups were detected and compared.The expression levels of the above indicators of different child-pugh grading and etiology in the observation group were compared. Results The expression levels of Th17 cell frequency and related cytokines of observation group were all higher than those of control group (P < 0.05),the expression levels of patients with higher Child-Pugh classification were all higher than those of patients with lower classification(P < 0.05),and the expression levels of patients with different etiology were compared,with no statistical significances(P > 0.05). Conclusion The expression of Th17 and related cytokines in the patients with hepatic cirrhosis are significantly abnormal,and the degree of liver injury has certain influence for the expression levels.Attention should be paid to the monitoring of the above indicators in patients with hepatitis cirrhosis.