不同剂量孕激素治疗无排卵型月经失调的临床价值分析

The clinical value of different doses of progesterone in the treatment of anovulatory menstrual disorder

目的研究分析不同剂量孕激素治疗无排卵型月经失调的临床价值。方法收集2015年1月～2018年12月我院收治的无排卵型月经失调患者90例作为研究对象,所有患者均接受孕激素治疗,按照不同的用药剂量将这90例患者均分为3组,I组患者用药剂量为100mg/d,II组患者用药剂量为200 mg/d,III组用药剂量为300 mg/d。对比分析三组患者临床治疗效果。结果 I组、II组、III组患者的临床治疗有效率差异不明显(P>0.05)不具有统计学意义;三组患者治疗前的子宫内膜厚度无明显差异(P>0.05),治疗后三组患者的子宫内膜厚度均明显改善,但三组间数据差异不明显;III组患者并发症发生率明显高于I组、II组,(P<0.05)具有统计学意义。结论在无排卵型月经失调的临床治疗中不同剂量孕激素治疗效果接近,均能够有效改善患者子宫内膜厚度,但大剂量孕激素治疗安全性明显低于常规剂量与小剂量,在临床治疗中应首选小剂量。

Objective To study the clinical value of different doses of progesterone in the treatment of anovulatory menstrual disorders.Methods 90 patients with anovulatory menstrual disorder who were admitted to our hospital from January 2015 to December 2018 were selected as the study subjects. All patients were treated with progesterone.The 90 patients were divided into three groups according to different doses.The dosage of the drug in group I was 100 mg/d,in group II was 200 mg/d,and in group III was 200 mg/d.It's 300mg/ d.The clinical effects of the three groups were compared and analyzed.Results There was no significant difference in the effective rate of clinical treatment among group I,group II and group III (P>0.05);there was no significant difference in the thickness of endometrium between the three groups before treatment (P>0.05). The thickness of endometrium in the three groups improved significantly after treatment, but there was no significant difference among the three groups. The incidence of hair loss was significantly higher than that in group I and group II (P<0.05).Conclusion Different doses of progesterone in the treatment of anovulatory menstrual disorder have similar therapeutic effect, and can effectively improve the endometrial thickness of patients,but the safety of high dose progesterone treatment is significantly lower than that of conventional dose and low dose progesterone treatment, low dose should be preferred in clinical treatment.