肌少症与骨质疏松症相关性研究进展

Research progress on correlation between sarcopenia and osteoporosis

肌肉减少症(肌少症)和骨质疏松症是老年人增龄过程中不可避免的2种疾病。肌量减少影响身体平衡,肌少症患者跌倒及骨折风险高。骨质疏松症表现为骨量减少和骨组织微结构破坏,骨折风险增加。尽早对骨质疏松症及肌少症进行干预治疗,可降低老年人跌倒发生率和骨折率,提高生活质量。有学者称肌少症与骨质疏松症为"活动障碍综合征",两者关系紧密。该文将从概念、危险因素、发病机制、流行病学、诊断标准和治疗方面对两者的相关性及研究进展进行综述。

Sacropenia and osteoporosis are two types of diseases that inevitably occur during the process of aging. Patients with sacropenia have a high risk of falling and fracture because the reduction of muscle mass affects the body balance. Osteoporosis is characterized by osteopenia and destruction of bone microstructure, which increases the risk of fracture. Early interventions are recommended for patients diagnosed with osteoporosis and sarcopenia to reduce the possibility of falling and fracture and enhance the quality of life of elderly population. Some scholars have claimed that sarcopenia and osteoporosis belong to "activity disorder syndromes", which are intimately correlated. In this article, the research progress on the correlation between sarcopenia and osteoporosis was reviewed from the perspectives of concept, risk factors, pathogenesis, epidemiology, diagnostic criteria and clinical treatment.