青年乳腺癌患者的临床特征及分子分型分析

Analysis of clinical characteristics and molecular subtypes of breast carcinoma in young women

目的探讨青年乳腺癌患者的临床特征及分子分型情况。方法选取年龄≤35岁的128例青年乳腺浸润性导管癌患者,以及同期年龄﹥35岁的130例中老年乳腺浸润性导管癌患者,分别作为青年组和中老年组。比较两组患者的临床特征和分子分型的差异。结果青年组和中老年组乳腺浸润性导管癌患者肿瘤直径、临床分期情况、淋巴结转移数目和Ki-67阳性表达率比较,差异均有统计学意义(P﹤0.01);但两组患者组织学分级、雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)表达情况比较,差异均无统计学意义(P﹥0.05)。青年组与中老年组乳腺浸润性导管癌患者Luminal A型、Luminal B型、HER2过表达型和三阴性乳腺癌分子分型情况比较,差异无统计学意义(P﹥0.05)。结论青年乳腺癌患者的肿瘤直径较大,病理分期较晚,Ki-67阳性表达率≥14%的比例较高,但与中老年乳腺癌患者的分子分型无明显差异,应早期筛查并给予积极治疗。

Objective To explore the clinical characteristics and molecular subtypes of breast carcinoma in young patients. Method The clinical data of 128 young patients (age≤35) with infiltrating ductal carcinoma were collected and analyzed retrospectively, another 130 middle-aged and elderly patients (age>35) with infiltrating ductal carcinoma were enrolled during the same period, they were divided into youth group and middle-aged and elderly group. The clinical characteristics as well as the molecular subtypes of breast carcinoma of the two groups were compared. Result The breast carcinoma in youth group were significantly different from the middle-aged and elderly group in regard to tumor size, clinical staging, lymph node metastasis and the positive expression of Ki-67, with statistically significant differences observed (P<0.05);however, there were no evident difference in the histological grading, expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) between the two groups (P> 0.05). Additionally, the distribution of molecular subtypes of Luminal A type, Luminal B type, HER2 overexpression type and triple-negative breast carcinoma were similar between youth group and middle-aged and elderly group (P>0.05). Conclusion Compared with middle- aged and elderly patients, the infiltrating ductal carcinoma in young patients are with larger size, advanced clinicopathological stage and higher expression of Ki- 67≥14%, nevertheless, the molecular subtypes are comparable in either age group, necessitating the early screening and active treatment.