126例奥沙利铂不良反应文献分析

Literature Analysis of 126 Cases of Adverse Drug Reactions Induced by Oxaliplatin

目的探讨奥沙利铂致不良反应的规律和特点,为临床合理用药提供参考。方法检索2000年1月至2018年5月中国期刊全文数据库(CNKI)有关奥沙利铂致不良反应文献,对收集的126例个例文献进行整理与分析。结果神经毒性和过敏类反应是奥沙利铂的主要不良反应,另外还有血液毒性、肾毒性和心脏毒性等;涉及多个系统损害,以呼吸系统损害、全身性损害及中枢及外周神经系统损害为主,临床表现复杂多样。女性略高于男性,不良反应用药前30 min内更易发生,6 h内发生的占85%以上。结论临床上应加强奥沙利铂不良反应的监测,积极预防。

Objective To investigate the laws and characteristics of adverse drug reactions (ADRs) induced by oxaliplatin, and to provide references for the clinical rational use of drugs. Methods To retrieve the related literature of the adverse reactions induced by oxaliplatin in CNKI from January, 2000 to May, 2018, and to analyze the 126 cases collected from the samples of literature. Results The main adverse reactions induced by oxaliplatin involved neurotoxicity and anaphylaxis, as well as blood toxicity, nephrotoxicity and cardiac toxicity, which caused much damage on the multiple systems, mainly including respiratory system, whole system, central and peripheral nervous system, with the complex and diverse clinical features. The adverse reactions were more likely to occur within 30 minutes after medication, in which more than 85% occur within 6 hours, and the ratio in women was slightly higher than in men. Conclusion Supervision and precaution should be strengthened in the clinical use of oxaliplatin.