104例颠茄磺苄啶片不良反应报告分析

Analysis of 104 Cases of Adverse Drug Reactions Induced by Belladonna Sulfamethoxazole and Trimerhoprim Tablets

目的分析颠茄磺苄啶片致不良反应(ADR)的发生特点,为用药安全提供参考。方法对2017年江西省药品不良反应监测中心收集到的104例颠茄磺苄啶片不良反应报告进行分析。结果男性患者数量是女性的1.89倍,以15～44岁的患者居多;不良反应表现主要为皮肤及附件损害(51.95%)、消化系统损害(22.73%)、全身性损害(9.74%);有42例患者未被询问既往不良反应,2例超适应证用药,12例新的不良反应。结论药店应做好用咨询服务,凭处方售卖处方药品,防止药物错用、滥用;临床应重视颠茄磺苄啶片引起的不良反应,警惕男性生殖系统损伤等新的不良反应的发生。

Objective To analyze the characteristics of adverse drug reactions (ADRs) of belladonna sulfamethoxazole and trimerhoprim tablets, so as to provide reference for public safe medication. Methods 104 cases of ADRs of belladonna sulfamethoxazole and trimerhoprim tablets collected by the Jiangxi Center for ADR Monitoring in 2017, were analyzed. Results Male patients were 1.89 times that of females, the most of patients were 15 to 44 years old. Clinical manifestations were mainly skin and its accessories damage (51.95%), digestive system damage (22.73%), and systemic damage (9.74%). Past histories of adverse drug reactions of 42 cases of patients were not inquired, 2 cases were off-label drug use, 12 cases were new ADR reports. Conclusion The pharmacy should provide consultation services, sell prescription drugs by prescriptions and prevent misuse and abuse of drugs. The clinic should pay attention to the ADRs by belladonna sulfamethoxazole and trimerhoprim tablets, and alert new ADRs such as male reproductive system damage.