质子泵抑制剂致血液系统不良反应的特点及机制分析

Analysis of Characteristics and Mechanism of Blood System Adverse Drug Reactions Induced by Proton Pump Inhibitors

目的探讨质子泵抑制剂(proton pump inhibitors, PPIs)致血液系统不良反应(ADR)的机制和特点,为临床合理用药提供参考。方法检索2000至2017年中国全文期刊数据库(CNKI)、维普中文科技期刊数据库以及万方数据库公开发表的质子泵抑制剂血液系统相关不良反应病例进行分析。结果共检索到87例发生血液系统不良反应的患者,其中男性及老年患者血液系统不良反应发生比例较高,一般在给药后一周内发生,其中奥美拉唑血液系统不良反应比例最高,主要包括白细胞减少、粒细胞减少、血小板减少等。结论临床应用质子泵抑制剂过程中应注意其血液系统不良反应,及时监测血常规,保证患者用药安全。

Objective To explore the mechanism and characteristics of adverse drug reactions(ADRs) induced by proton pump inhibitors(PPIs) in the blood system, so as to provide a reference for rational clinical use of drugs. Methods Blood system ADR cases induced by PPIs which were reported in main medical journals published from 2000 to 2017 were collected by retrieving CNKI, Weipu and Wanfang databases and were analyzed. Results In 87 patients, males and elderly patients have the higher ratios of ADR in the blood system, and commonly occured within one week after the treatment. Omeprazole may have the highest ratios of blood system ADR, mainly including leukopenia, granulocytopenia, thrombocytopenia, and so on. Conclusion Great importance should be attached to the blood system ADR induced by PPIs in the clinic, and the blood should be monitored in time to ensure the medication safety of patients.