益气健脾汤辅助二甲双胍治疗脾气亏虚型2型糖尿病患者临床效果评价

Clinical evaluation of Yiqi Jianpi Decoction assisted with metformin for patients with type 2 diabetes mellitus of spleen-qi deficiency

目的探讨益气健脾汤辅助二甲双胍治疗脾气亏虚型2型糖尿病的临床效果。方法选取2017年3月至2018年2月在我院就诊的脾气亏虚型2型糖尿病患者50例为研究对象,采用随机数字表法分为对照组与观察组,每组25例。两组患者均进行饮食调节、运动等基础治疗。在此基础上,对照组患者给予二甲双胍治疗,观察组患者在对照组治疗基础上加服益气健脾汤辅助治疗,两组患者均连续治疗3个月。比较两组患者的中医症候评分、糖化血红蛋白水平、血糖水平以及胰岛素水平。结果治疗3个月后,两组患者的中医症候评分、观察组患者的糖化血红蛋白水平均显著降低,观察组患者的中医症候评分及糖化血红蛋白水平均显著低于对照组,差异有统计学意义(P <0. 05);两组患者的空腹血糖、餐后1h血糖及餐后2h血糖水平均显著降低,观察组患者的空腹血糖、餐后1h血糖及餐后2h血糖水平均显著低于对照组,差异有统计学意义(P <0. 05);两组患者空腹胰岛素水平和胰岛素抵抗指数均显著降低,观察组患者空腹胰岛素水平和胰岛素抵抗指数均显著低于对照组,差异有统计学意义(P <0. 05)。结论益气健脾汤能有效缓解脾气亏虚型2型糖尿病患者中医症候,改善糖代谢及胰岛素抵抗状况。

Objective To investigate the clinical effect of Yiqi Jianpi Decoction assisted with metformin for patients with type 2 diabetes mellitus of spleen-qi deficiency.Methods A total of 50 patients with type 2 diabetes mellitus of spleen-qi deficiency who were treated in our hospital from March 2017 to February 2018 were selected as subjects and randomly divided into the control group and the observation group,with 25 cases in each group.Two groups underwent basic treatments such as diet and exercise.On this basis,patients in control group were treated with metformin,and observation group were further treated with Yiqi Jianpi Decoction on the treatment of control group.The patients in two groups were treated for 3 months.Traditional Chinese medicine(TCM)syndrome score,glycated hemoglobin level,blood glucose level,and insulin level were compared between the two groups.Results After treatment for 3 months,the TCM syndrome score of two groups and the glycated hemoglobin level of the observation group were significantly decreased,the TCM syndrome score and glycated hemoglobin level of observation group were significantly lower than those in control group,and the difference was statistically significant(P<0.05).The fasting blood glucose,1-hour postprandial blood glucose and 2-hour postprandial blood glucose levels were significantly decreased in two groups and observation group were significantly lower than control group on these indicators,and the difference was statistically significant(P<0.05).The fasting insulin level and insulin resistance index were significantly decreased in two groups and observation group were significantly lower than the control group on these indicators,the difference was statistically significant(P<0.05).Conclusion Yiqi Jianpi Decoction can effectively alleviate TCM syndrome,improve glucose metabolism and insulin resistance in patients with type 2 diabetes mellitus whose spleen-qi are deficient.