血清IMA、MCP-1、CD163表达水平与急性冠脉综合征患者病情严重程度的关系研究

Relationship Between Serum Levels of IMA,MCP-1 and CD163 and Severity of Acute Coronary Syndrome

目的研究血清IMA、MCP-1、CD163表达水平与急性冠脉综合征患者病情严重程度的关系。方法本研究的研究对象以2017年1月至2018年1月在我院诊治的100例ACS患者为观察组,同期100例非缺血性胸痛患者为对照组,分别对两组患者的血清IMA、MCP-1、CD163表达水平进行对比,对观察组患者的以上指标进行多因素相关回归分析。结果观察组患者的IMA、MCP-1、CD163水平与Gensini评分、血浆NT-proBNP水平明显高于对照组,差异具有统计学意义(P <0.05),观察组患者随着病情的加重,其血清IMA、MCP-1、CD163水平与Gensini评分、血浆NT-proBNP水平呈明显上升趋势;患者血清IMA、MCP-1、CD163这三个指标都是水平越高、Gensini评分越高,血浆NT-proBNP水平越高,呈现正相关;血清IMA、血清MCP-1、血清CD163均为ACS的独立危险因素,而血清HDL为ACS的保护因素。结论 IMA、MCP-1、CD163与NT-proBNP水平和Gensini评分均呈正相关关系,与HDL均是ACS的独立危险因素,有望成为ACS病情评估和预后预测的指标。

Objective To study the relationship between serum levels of IMA,MCP-1 and CD163 and severity of acute coronary syndrome. Methods The subjects of this study were 100 ACS patients who were treated in our hospital from January,2017 to January,2018,and 100 non-ischemic chest pain patients during the same period as the control group. The levels of serum IMA,MCP-1 and CD163 were compared between the two groups,and the observation group were analyzed by multivariate regression analysis. Results The levels of IMA,MCP-1 and CD163 in the observation group were significantly higher than those in the control group ( P < 0.05),the same as Gensini score and plasma NT-proBNP ( P < 0.05). The higher the serum IMA,MCP-1 and CD163 levels,the higher the Gensini score and the plasma NT-proBNP level,showing a positive correlation. Serum IMA,MCP-1 and CD163 were all independent risk factors for ACS,while serum HDL was the protective factor for ACS. Conclusion IMA,MCP-1,CD163 were positively correlated with NT-proBNP content and Gensini score. Both IMA,MCP-1,CD163 and HDL were independent risk factors for ACS,and could be used as indicators for evaluating the disease condition and to predict the prognosis of ACS.