膈下逐瘀汤联合穴位埋线对肥胖型多囊卵巢综合征不孕症的临床疗效观察

The Clinical effect of Under the diaphragm by stasis soup combinated with Point thread-embedding on Infertility patients with Obesity-type polycystic ovary Syndrome

目的:膈下逐瘀汤联合穴位埋线治疗肥胖型多囊卵巢综合征(PCOS)不孕症患者,总结其对糖脂代谢、排卵、妊娠情况的影响。方法:选择我院160例PCOS不孕症患者,随机分为对照组(n=80)与观察组(n=80)。对照组给予二甲双胍+膈下逐瘀汤口服,观察组在对照组的基础上给予穴位埋线治疗。两组均给予3个月的治疗周期。测量并比较两组治疗前与治疗结束后的体重指数(BMI)、腰臀比(WHR)、外周血清血脂[低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、甘油三酯(TG)]、血糖[空腹血浆胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、空腹血糖(FPG)、餐后2 h血糖(2 hPG)]、激素水平[雌激素(E_2)、睾酮(T)、卵泡雌激素(FSH)、黄体生成素(LH)],并评估患者的妊娠情况。结果:治疗后两组外周血清LH、LH/FSH、E_2、T、TG、LDL-C、TC、FPG、2 hPG、BMI、WHR均较治疗前有所降低,且观察组低于对照组,差异均有统计学意义(P<0.05);治疗后两组外周血清HDL-C、FSH较治疗前有所升高,且观察组高于对照组,差异均有统计学意义(P<0.05);观察组的排卵率及其临床妊娠率均高于对照组,差异均有统计学意义(P<0.05)。结论:在膈下逐瘀汤治疗的基础上给予穴位埋线能通过改善PCOS不孕症患者的糖脂代谢异常与外周血清性激素水平而提高患者的排卵率与临床妊娠率。

Objective:To study the clinical effect of under the diaphragm by stasis soup combinated with point thread-embedding on infertility patients with obesity-type polycystic ovary syndrome(PCOS)and evaluate the the rate of ovulation and pregnancy.Methods:Selceting 100 infertility patients with obesity-type PCOS,then they were randomly divided into control group(n=80)and observation group(n=80).The control group patients were given metformin+ under the diaphragm by stasis soup,the observation group were given metformin+exenatide+ point thread-embedding,they were treated 3 months.Before and after treatment,we observed the changes of body mass index(BMI),waist-to-hipratio(WHR),fasting plasma glucose(FBG),2-hour postprandial blood glucose(2hPBG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),homeostasis model assessment of insulin resistance(HOMA-IR),fasting plasma insulin(FINS),follicule-stimulating hormone(FSH),luteinizing hormone(LH),LH/FSH,estrogen(E2),and testosterone(T).At last,we assessed the rate of ovulation and pregnancy.Results:After the treatment,the FBG,2 hPBG,TC,LDL-C,TG,BMI,WHR,HOMA-IR,FINS,LH,LH/FSH,E 2,and T were lower than before treatment in both groups,and the difference had statistical significance(P<0.05),and the observation group were lower than control group,and the difference had statistical significance(P<0.05);the HDL-C and FSH were higher than before treatment in both groups,and the difference had statistical significance(P<0.05),and the observation group were higher than control group,and the difference had statistical significance(P<0.05).The rate of ovulation and pregnancy in the observation group were higher than control group,and the difference had statistical significance(P<0.05).Conclusions:Under the diaphragm by stasis soup combinated with point thread-embedding can improve the metabolize of carbohydrate and lipid,and the abnormity of sex hormones,through this process,the rate of ovulation and pregnancy can be raised.