难治性精神分裂症药物基因检测CYP相关性研究

CYP correlation study of refractory schizophrenia drug gene detection

目的:研究精神分裂症的难治性相关因素。方法:选取200例难治性精神分裂症患者和200例非难治性精神分裂症患者,药物基因检测他们的CYP系列基因CYP1A2、CYP3A4、CYP2D6,对3个基因的快代谢型概率进行比较分析;再将200例难治性精神分裂症患者随机分为合并药物治疗组、单一药物治疗组各100例,分别于治疗的0W、4W进行药物基因检测3个基因快代谢型以及BPRS量表评分疗效进行比较分析。结果:难治性精神分裂症患者CYP1A2、CYP3A4、CYP2D6基因快代谢型概率与非难治性差异具有显著性(P<0.05);治疗4 W后合并药物治疗组CYP1A2、CYP3A4、CYP2D6基因快代谢型概率对比单一药物治疗组差异无显著性(P>0.05);BPRS量表评分合并药物治疗组疗效显著高于单一药物治疗组(P<0.05);经过Logistic回归分析,精神分裂症的难治性与CYP系列基因CYP1A2、CYP3A4、CYP2D6快代谢型相关。结论:CYP系列基因CYP1A2、CYP3A4、CYP2D6快代谢型是精神分裂症难治性的相关因素,抗精神病药物合并CYP酶抑制剂治疗能够提高疗效。

Objective:To study the refractory factors associated with schizophrenia.Methods:A total of 200 patients with refractory schizophrenia and 200 patients with non-refractory schizophrenia were selected.The CYP series of genes CYP1A2,CYP3A4 and CYP2D6 were detected by drug gene,and the rapid metabolic probabilities of the three genes were compared and analyzed.200 patients with refractory schizophrenia were randomly divided into two groups:the combined drug treatment group and the single drug treatment group.The results were compared between the treatment of 0W and 4W for drug gene detection,3 genes fast metabolizing type and BPRS scale analysis.Results:The rapid metabolizing probability and non-refractory difference of CYP1A2,CYP3A4 and CYP2D6 genes in patients with refractory schizophrenia were significant(P<0.05).The comparison of fast metabotropic probabilities of CYP1A2,CYP3A4 and CYP2D6 genes in patients treated with 4W after treatment There was no significant difference in the single drug treatment group(P>0.05).The BPRS scale score was significantly higher in the drug-treated group than in the single-drug group(P<0.05).After logistic regression analysis,the refractory characteristics of schizophrenia and The CYP series of genes CYP1A2,CYP3A4,and CYP2D6 are rapidly metabolized.Conclusion:CYP series of genes CYP1A2,CYP3A4,CYP2D6 fast metabolites are related factors of refractory schizophrenia,antipsychotic drugs combined with CYP enzyme inhibitor treatment can improve the efficacy.