高龄急性缺血性脑卒中患者rt-PA静脉溶栓预后影响因素分析

Prognostic Factors of Intravenous rt-PA Thrombolytic Therapy on Elderly Patients with Acute Ischemic Stroke

目的探讨影响重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗高龄(年龄≥80岁)急性缺血性脑卒中患者预后的相关因素分析。方法回顾性分析67例高龄急性缺血性脑卒中患者的相关临床资料,按90d临床结局改良Rankin量表(mRS)评分将患者分为预后良好组(mRS≤2分)和预后不良组(mRS>2分),以上数据均进行统计学描述,同时进行Logistic回归分析。结果多因素Logistic回归分析提示溶栓前舒张压、溶栓前血糖、24h神经功能缺损评分(NIHSS)均具有统计学意义(P<0.05)。结论对于高龄急性缺血性脑卒中患者静脉rt-PA溶栓,24hNIHSS评分、溶栓前血糖、溶栓前舒张压是影响其预后的独立影响因素。

Objective To analyze the prognostic factors of intravenous rt-PA thrombolytic therapy on elderly patients (≥80)with acute ischemic stroke. Methods Clinical data of 67 aged patients with acute ischemic stroke were analyzed retrospectively. Patients were divided into good-outcome group(mRS≤2) and bad-outcome group (mRS>2)according to the mRS score. These data were statistically described and were analyzed by the logistic multivariate analysis. Results Logistic multivariate analysis showed that baseline diastolic pressure, baseline blood glucose, and 24 hrs NIHSS score were all statistically significant ( P <0.05). Conclusions Baseline blood glucose, baseline blood glucose and 24 hrs NIHSS score are the independent factors of intravenous rt-PA thrombolytic therapy for aged patients with acute ischemic stroke.