氧化应激在强直性脊柱炎发病机制中的作用

Role of oxidative stressin in the pathogenesis of ankylosing spondylitis

强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性炎性反应性自身免疫性疾病,男性发病率高于女性,病理性骨化是其最显著的特征,但发病机制至今仍不清楚。目前用于治疗AS的主要药物包括NSAIDs和TNF-α拮抗剂都可以明显改善症状,但尚不能阻止病理性骨化发生。有研究发现,AS存在促氧化剂和抗氧化剂稳态失衡。本文综述氧化应激和强直性脊柱炎两者之间的关系及AS的发病机制。

Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, which has higher incidence in male. Pathologic ossification is the main clinical feature. However, the pathogenesis of AS is still unclear. The main drugs currently used for treatment, including NSAIDs and TNF-α antagonists, can significantly improve symptoms but cannot prevent pathological ossification. Some studies demonstrated that an imbalance of pro-oxidant and antioxidant existed in AS patients. This paper reviewed the progression on the research of oxidative stress in the pathogenesis of ankylosing spondylitis.