摘要
强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性炎性反应性自身免疫性疾病,男性发病率高于女性,病理性骨化是其最显著的特征,但发病机制至今仍不清楚。目前用于治疗AS的主要药物包括NSAIDs和TNF-α拮抗剂都可以明显改善症状,但尚不能阻止病理性骨化发生。有研究发现,AS存在促氧化剂和抗氧化剂稳态失衡。本文综述氧化应激和强直性脊柱炎两者之间的关系及AS的发病机制。
Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, which has higher incidence in male. Pathologic ossification is the main clinical feature. However, the pathogenesis of AS is still unclear. The main drugs currently used for treatment, including NSAIDs and TNF-α antagonists, can significantly improve symptoms but cannot prevent pathological ossification. Some studies demonstrated that an imbalance of pro-oxidant and antioxidant existed in AS patients. This paper reviewed the progression on the research of oxidative stress in the pathogenesis of ankylosing spondylitis.
作者
崔艳铭
崔阳
CUI Yan-ming;CUI Yang(Department of Rheumatology and Immunology,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510080,China;Second Clinical Medical College of Southern Medical University,Guangzhoa 510515,China)
出处
《中华临床免疫和变态反应杂志》
2018年第6期633-636,共4页
Chinese Journal of Allergy & Clinical Immunology
关键词
强直性脊柱炎
氧化应激
抗氧化作用
Ankylosing spondylitis
Oxidative stress
Antioxidation