期刊文献+

雷帕霉素与大脑皮质发育障碍关系的研究进展

下载PDF
导出
摘要 本文简要综述了雷帕霉素与大脑皮质发育障碍关系的研究进展,并阐述了雷帕霉素在治疗脑皮质发育障碍中的重要地位,旨在为临床治疗难治性癫痫提供有效的参考依据。
作者 苟伟 马勋泰
出处 《现代临床医学》 2019年第2期88-90,共3页 Journal of Modern Clinical Medicine
基金 四川省卫生厅科研基金
  • 相关文献

参考文献2

二级参考文献66

  • 1Balduini W, Carloni S, Buonocore G (2012) Autophagy in hypox- ia-ischemia induced brain injury. J Matern Fetal Neonatal Med 25 Suppl 1:30-34.
  • 2Chen L, Xu B, Liu L, Luo Y, Yin L Zhou H, Chen W, Shen T, Hart X, Huang S (2010) Hydrogen peroxide inhibits mT.
  • 3OR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest 90:762-773. Chen TJ, Wang DC, Chen SS (2009) Amyloid-beta interrupts the PI3K- Akt-mTOR signaling pathway that could be involved in brain-de- rived neurotrophic factor-induced Arc expression in rat cortical neurons. J Neurosci Res 87:2297-2307.
  • 4Choi KC, Kim SH, Ha JY, Kim ST, Son JH (2010) A novel mTOR acti- vating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem 112:366-376.
  • 5Chong ZZ, Shang YC, Wang S, Maiese K (2012a) PRAS40 is an integral regulatory component of erythropoietin mTOR signaling and cyto- protection. PLoS One 7:e45456.
  • 6Chong ZZ, Shang YC, Wang S, Maiese K (2012b) Shedding new light on neurodegenerative diseases through the mammalian target of rapa- mycin. Prog Neurobiol 99:128-148.
  • 7Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ (2006) Hypothalamic mTOR signaling regulates food intake. Sci- ence 312:927-930.
  • 8GangloffYG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, Um SH, Brown EJ, Cereghini S, Thomas G, Kozma SC (2004) Disruption of the mouse roTOR gene leads to early postimplantation lethali- ty and prohibits embryonic stem cell development. Mol Cell Biol 24:9508-9516.
  • 9Gong R, Park CS, Abbassi NR, Tang SJ (2006) Roles of glutamate re- ceptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippo- campal neurons. J Biol Chem 281:18802-18815.
  • 10Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O'Connor R, O'Neill C (2005) Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J Neurochem 93:105-117.

共引文献23

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部